Document Detail

Hypertension as a possible complication of recombinant human erythropoietin therapy.
MedLine Citation:
PMID:  2040173     Owner:  NLM     Status:  MEDLINE    
The analysis of the hemodynamics accompanying correction of renal anemia by rhEPO shows that--although they behave qualitatively as in nonuremic anemic patients--cardiac output and peripheral resistance may change inadequately and thereby cause a rise of blood pressure. The underlying mechanisms are not yet fully understood but to a great part may be related to preexisting pathology due to a history of longlasting hypertension. In some patients the development of hypertension may only represent a temporary phenomenon of hemodynamic dysregulation. To avoid cardiovascular complications the following should be considered: Patients with a history of hypertension, even if they are normotensive in the anemic state, are at a higher risk of developing hypertension during therapy with rhEPO. Hypertensive complications may be rare events when anemia is corrected slowly. In case of the development or aggravation of hypertension a reduction of the target hematocrit is indicated.
R Brunkhorst; B Nonnast-Daniel; K M Koch; U Frei
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Contributions to nephrology     Volume:  88     ISSN:  0302-5144     ISO Abbreviation:  Contrib Nephrol     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-11     Completed Date:  1991-07-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513582     Medline TA:  Contrib Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  118-25; discussion 126     Citation Subset:  IM    
Abteilung Nephrologie, Medizinische Hochschule Hannover, FRG.
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MeSH Terms
Anemia / drug therapy*
Cardiac Output / drug effects
Erythropoietin / adverse effects*
Hypertension / etiology*
Kidney Failure, Chronic / complications*
Recombinant Proteins / adverse effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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