| Hypertension as a possible complication of recombinant human erythropoietin therapy. | |
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MedLine Citation:
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PMID: 2040173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The analysis of the hemodynamics accompanying correction of renal anemia by rhEPO shows that--although they behave qualitatively as in nonuremic anemic patients--cardiac output and peripheral resistance may change inadequately and thereby cause a rise of blood pressure. The underlying mechanisms are not yet fully understood but to a great part may be related to preexisting pathology due to a history of longlasting hypertension. In some patients the development of hypertension may only represent a temporary phenomenon of hemodynamic dysregulation. To avoid cardiovascular complications the following should be considered: Patients with a history of hypertension, even if they are normotensive in the anemic state, are at a higher risk of developing hypertension during therapy with rhEPO. Hypertensive complications may be rare events when anemia is corrected slowly. In case of the development or aggravation of hypertension a reduction of the target hematocrit is indicated. |
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Authors:
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R Brunkhorst; B Nonnast-Daniel; K M Koch; U Frei |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Contributions to nephrology Volume: 88 ISSN: 0302-5144 ISO Abbreviation: Contrib Nephrol Publication Date: 1991 |
Date Detail:
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Created Date: 1991-07-11 Completed Date: 1991-07-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7513582 Medline TA: Contrib Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 118-25; discussion 126 Citation Subset: IM |
Affiliation:
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Abteilung Nephrologie, Medizinische Hochschule Hannover, FRG. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
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drug therapy* Cardiac Output / drug effects Erythropoietin / adverse effects* Humans Hypertension / etiology* Kidney Failure, Chronic / complications* Recombinant Proteins / adverse effects Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 11096-26-7/Erythropoietin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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