Document Detail

Hypertension as a low-grade systemic inflammatory condition that has its origins in the perinatal period.
MedLine Citation:
PMID:  16715619     Owner:  NLM     Status:  MEDLINE    
Genetics, oxidative stress: superoxide anion (O2*-) and hydrogen peroxide (H2O2), endothelial nitric oxide (eNO), lipid peroxides, anti-oxidants, endothelin, angiotensin converting enzyme (ACE) activity, angiotensinII, transforming growth factor-beta (TGF-beta), insulin, homocysteine, asymmetrical dimethyl arginine, proinflammatory cytokines: interleukin-6 (IL-6), tumor necrosis factor-a (TNF-alpha), C-reactive protein (hs-CRP), and long-chain polyunsaturated fatty acids (LCPUFAs), and activity of NAD(P)H oxidase have a role in human essential hypertension. There is a close interaction between endogenous molecules: eNO, endothelin, cytokines, and nutrients: folic acid, L-arginine, tetrahydrobiopterin (H4B), vitamin B6, vitamin B12, vitamin C, and LCPUFAs. Statins mediate some, if not all, of their actions through LCPUFAs, whereas these fatty acids (especially omega-3 fatty acids) suppress cyclo-oxygenase activity and the synthesis of pro-inflammatory cytokines, and activate parasympathetic nervous system, actions that reduce the risk of major vascular events. Some LCPUFAs form precursors to lipoxins and resolvins that have anti-inflammatory actions. Low-grade systemic inflammation seen in hypertension seems to have its origins in the perinatal period and availability of adequate amounts of LCPUFAs during the critical periods of brain growth prevents the development of hypertension. This indicates that preventive strategies aimed at decreasing the incidence of hypertension and its associated conditions such as atherosclerosis, type 2 diabetes, coronary heart disease (CHD), and cardiac failure in adulthood need to be instituted during the perinatal period if they are to be effective.
U N Das
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of the Association of Physicians of India     Volume:  54     ISSN:  0004-5772     ISO Abbreviation:  J Assoc Physicians India     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-05-23     Completed Date:  2006-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505585     Medline TA:  J Assoc Physicians India     Country:  India    
Other Details:
Languages:  eng     Pagination:  133-42     Citation Subset:  IM    
UND Life Sciences, 13800 Fairhill Road, Shaker Heights, OH 44120, USA.
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MeSH Terms
Hypertension / diagnosis,  physiopathology*
Inflammation / physiopathology*
Oxidative Stress / physiology
Postpartum Period*
Reg. No./Substance:
11062-77-4/Superoxides; 454-28-4/Homocysteine

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