| Hypertension, antihypertensive therapy and renal-cell cancer: a meta-analysis. | |
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MedLine Citation:
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PMID: 18690958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship between hypertension, antihypertensive treatments and the risk of renal-cell cancer (RCC) remains still controversial. To evaluate the strength of the evidence provided by the epidemiological literature on this topic, a MEDLINE search of the papers published from 1966 to 2006 was performed. A total of 18 studies were included in the analysis. Pooled estimates of the effects of interest were obtained by fitting random effect models to the original data. The effects of some characteristics of the studies were considered as putative sources of heterogeneity of the estimates. Significant increased risks of RCC associated with hypertension (pooled odds ratio 1.62; 95% confidence interval: 1.24 to 2.12), as well as with the use of both diuretics (1.43; 1.12 to 1.83) and no diuretics (1.51; 1.21 to 1.87) antihypertensive drugs were observed. The effect of diuretics was significant in women (1.92; 1.59 to 2.33), but not in men (1.18; 0.93 to 1.49). Allowance for the known risk factors of RCC appreciably modified the effect of no diuretic antihypertensives making its pooled estimate not significant (1.17; 0.94 to 1.46). Although the pooled estimates show that both, hypertension and hypertensive therapy, are statistically associated with increased risk of RCC, experimental data and a closer look on the original data from epidemiologic literature, show that available evidence are still uncertain and need to be further investigated. |
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Authors:
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Giovanni Corrao; Lorenza Scotti; Vincenzo Bagnardi; Roberto Sega |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current drug safety Volume: 2 ISSN: 1574-8863 ISO Abbreviation: - Publication Date: 2007 May |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101270895 Medline TA: Curr Drug Saf Country: Unknown |
Other Details:
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Languages: eng Pagination: 125-33 Citation Subset: IM |
Affiliation:
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Unit of Biostatistics and Epidemiology, Department of Statistics, University of Milano-Bicocca, Milan, Italy. giovanni.corrao@unimib.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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adverse effects*,
therapeutic use Carcinoma, Renal Cell / chemically induced, epidemiology* Diuretics / adverse effects, therapeutic use Female Humans Hypertension / complications*, drug therapy, epidemiology* Kidney Neoplasms / chemically induced, epidemiology* Male Odds Ratio Risk Factors Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Diuretics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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