| Hypertension and adrenal disorders. | |
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MedLine Citation:
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PMID: 7922187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormalities of adrenal cortical and medullary function are important causes of hypertension in adults. Mineralocorticoid hypertension, characterized by spontaneous hypokalemia with excessive kaliuresis and low plasma renin activity, is most commonly caused by aldosterone-producing adenoma or, less frequently, by nonadenomatous adrenal hyperplasia. However, recent evidence indicates that this classification oversimplifies the pathophysiologic diversity of this syndrome. Advances in steroid biochemistry and molecular biology have improved our ability to identify patients with various forms of mineralocorticoid hypertension and also provide evidence that they are underdiagnosed. Pheochromocytomas are most commonly located in the adrenal medulla, where they may overproduce norepinephrine or epinephrine. Appropriate screening of norepinephrine, epinephrine, and their metabolites is essential because tumors that secrete epinephrine exclusively may not present with hypertension and, thus, can be overlooked. Extra-adrenal pheochromocytomas are more prevalent than previously considered and pose special problems because they may be multicentric, difficult to locate, and more likely to be malignant than are adrenal pheochromocytomas. |
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Authors:
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J D Blumenfeld |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Current opinion in nephrology and hypertension Volume: 2 ISSN: 1062-4821 ISO Abbreviation: Curr. Opin. Nephrol. Hypertens. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1994-11-02 Completed Date: 1994-11-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9303753 Medline TA: Curr Opin Nephrol Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 274-82 Citation Subset: IM |
Affiliation:
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New York Hospital-Cornell University Medical Center, New York. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Diseases
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complications,
physiopathology* Animals Catecholamines / physiology Humans Hypertension / etiology, physiopathology* Mineralocorticoids / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL18323/HL/NHLBI NIH HHS; RR0007/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 0/Mineralocorticoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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