Document Detail

Hypertension and ace gene insertion/deletion polymorphism in pediatric renal transplant patients.
MedLine Citation:
PMID:  16176418     Owner:  NLM     Status:  MEDLINE    
The objective of the present study was to define the risk factors for hypertension and to analyze the influence of insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) on hypertension in pediatric renal transplant recipients. Twenty-six pediatric renal transplant recipients with stable renal function and treated with the same immunosuppression protocol were included in the study. Their mean age was 12.5 +/- 3.3 yr and mean time after transplantation was 38.5 +/- 39.8 month. Twenty-four hour ambulatory blood pressure monitoring (ABPM) was performed by SpaceLabs (90207) device. The I/D polymorphism of the ACE was determined by PCR and ACE serum level was analyzed by colorimetric method. Hypertension was present in 15 patients (57.7%) by causal blood pressure measurements and 19 patients (73.1%) by ABPM. Twenty-two patients (84.6%) were found to be non-dipper and eight of them had reverse dipping. Only time after transplantation (38 +/- 31 vs. 79 +/-49 month, p = 0.016) and cyclosporin A trough plasma levels (206 +/-78 vs. 119 +/- 83 ng/mL, p = 0.020) influenced the presence of hypertension by multiple logistic regression analysis. The distribution of genotypes were II = 2 (7.7%), ID = 8 (30.8%), DD = 16 (61.5%). There was no effect of ACE gene I/D polymorphism or serum ACE levels on hypertension prevalence and circadian variability of blood pressures. Hypertension was related to the time after transplantation and cyclosporin A levels. The ACE gene I/D polymorphism and serum ACE levels did not influence the blood pressure values or circadian variability of blood pressure among pediatric renal transplant patients.
Erkin Serdaroglu; Sevgi Mir; Afig Berdeli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric transplantation     Volume:  9     ISSN:  1397-3142     ISO Abbreviation:  Pediatr Transplant     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-22     Completed Date:  2006-01-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9802574     Medline TA:  Pediatr Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  612-7     Citation Subset:  IM    
Department of Pediatric Nephrology, Ege University Medical School, Izmir, Turkey.
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MeSH Terms
Blood Pressure Monitoring, Ambulatory
Hypertension / etiology,  genetics*
Immunosuppressive Agents / therapeutic use
Kidney Transplantation / adverse effects*
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Reg. No./Substance:
0/Immunosuppressive Agents; EC A

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