| A hypertension risk score for middle-aged and older adults. | |
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MedLine Citation:
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PMID: 21029343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Determining which demographic and medical variables predict the development of hypertension could help clinicians stratify risk in both prehypertensive and nonhypertensive persons. Subject-level data from 2 community-based biracial cohorts were combined to ascertain the relationship between baseline characteristics and incident hypertension. Hypertension, defined as diastolic blood pressure ≥90 mm Hg, systolic blood pressure ≥140 mm Hg, or reported use of medication known to treat hypertension, was assessed prospectively at 3, 6, and 9 years. Internal validation was performed by the split-sample method with a 2:1 ratio for training and testing samples, respectively. A scoring algorithm was developed by converting the multivariable regression coefficients to integer values. Age, level of systolic or diastolic blood pressure, smoking, family history of hypertension, diabetes mellitus, high body mass index, female sex, and lack of exercise were associated with the development of hypertension in the training sample. Regression models showed moderate to high capabilities of discrimination between hypertension vs nonhypertension (area under the receiver operating characteristic curve 0.75-0.78) in the testing sample at 3, 6, and 9 years of follow-up. This risk calculator may aide health care providers in guiding discussions with patients about the risk for progression to hypertension. |
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Authors:
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Abhijit V Kshirsagar; Ya-Lin Chiu; Andrew S Bomback; Phyllis A August; Anthony J Viera; Romulo E Colindres; Heejung Bang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 12 ISSN: 1751-7176 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2011-06-02 Revised Date: 2011-11-08 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 800-8 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Medicine, UNC Kidney Center and Division of Nephrology and Hypertension, School of Medicine, Chapel Hill, NC 27599, USA. sagar@med.unc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Algorithms Blood Pressure Cohort Studies Confidence Intervals Disease Progression Female Humans Hypertension / diagnosis*, pathology Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Risk Assessment |
| Grant Support | |
ID/Acronym/Agency:
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KL2RR025746/RR/NCRR NIH HHS; UL1-RR024996/RR/NCRR NIH HHS |
| Comments/Corrections | |
Comment In:
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J Clin Hypertens (Greenwich). 2011 Oct;13(10):780
[PMID:
21974767
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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