Document Detail


A hypertension risk score for middle-aged and older adults.
MedLine Citation:
PMID:  21029343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Determining which demographic and medical variables predict the development of hypertension could help clinicians stratify risk in both prehypertensive and nonhypertensive persons. Subject-level data from 2 community-based biracial cohorts were combined to ascertain the relationship between baseline characteristics and incident hypertension. Hypertension, defined as diastolic blood pressure ≥90 mm Hg, systolic blood pressure ≥140 mm Hg, or reported use of medication known to treat hypertension, was assessed prospectively at 3, 6, and 9 years. Internal validation was performed by the split-sample method with a 2:1 ratio for training and testing samples, respectively. A scoring algorithm was developed by converting the multivariable regression coefficients to integer values. Age, level of systolic or diastolic blood pressure, smoking, family history of hypertension, diabetes mellitus, high body mass index, female sex, and lack of exercise were associated with the development of hypertension in the training sample. Regression models showed moderate to high capabilities of discrimination between hypertension vs nonhypertension (area under the receiver operating characteristic curve 0.75-0.78) in the testing sample at 3, 6, and 9 years of follow-up. This risk calculator may aide health care providers in guiding discussions with patients about the risk for progression to hypertension.
Authors:
Abhijit V Kshirsagar; Ya-Lin Chiu; Andrew S Bomback; Phyllis A August; Anthony J Viera; Romulo E Colindres; Heejung Bang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  12     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-06-02     Revised Date:  2013-07-22    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  800-8     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc.
Affiliation:
Department of Medicine, UNC Kidney Center and Division of Nephrology and Hypertension, School of Medicine, Chapel Hill, NC 27599, USA. sagar@med.unc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Algorithms
Blood Pressure
Cohort Studies
Confidence Intervals
Disease Progression
Female
Humans
Hypertension / diagnosis*,  pathology
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Risk Assessment
Grant Support
ID/Acronym/Agency:
KL2 RR025746/RR/NCRR NIH HHS; KL2RR025746/RR/NCRR NIH HHS; UL1-RR024996/RR/NCRR NIH HHS
Comments/Corrections
Comment In:
J Clin Hypertens (Greenwich). 2011 Oct;13(10):780   [PMID:  21974767 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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