| Hypertension induced by episodic reductions in uteroplacental blood flow in gravid rat. | |
| | |
MedLine Citation:
|
PMID: 20846047 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background. The etiology of preeclampsia remains unclear. Animal modeling of preeclampsia has been useful; however, no model to date represents episodic changes in uteroplacental blood flow that may occur in preeclampsia. Objective. To develop a gravid rat model characterized by episodic reductions in uteroplacental blood flow. Method. Pregnant Sprague Dawley rats were used and subjected to SHAM, reduced uterine perfusion pressure (RUPP), or aortic occlusion on gestational Day 14. Aortic occlusion surgery consisted of implantation of a silastic vascular occluder around the abdominal aorta and silver clips around the uterine-ovarian arteries. Aortic occlusion animals were subjected to five consecutive days of occlusion (40% reduction) each session lasting 1 h. On Day 21, maternal mean arterial pressure (MAP) and fetal morphology were assessed. For isolated blood vessels, resistance-sized mesenteric arteries were harvested and mounted on a pressure arteriograph. Result. Occluder animals experienced a 10 mmHg rise in MAP as compared to SHAM (p < 0.05), and RUPP MAP was significantly increased as compared to control subjects (p < 0.05). Pups from Occluder animals exhibited a decrease in fetal weight as compared to SHAM (p < 0.05), but an increase in fetal weight as compared to RUPP (p < 0.05). Myogenic reactivity of second-order mesenteric arteries increased in Occluder animals as compared to SHAM (p < 0.05), but were similar to that of RUPP. Conclusion. Episodic reductions in uteroplacental blood flow play a crucial role in the altered vascular reactivity seen in Occluder animals and may represent a new model to investigate the mechanisms associated with episodic reductions in uteroplacental blood flow in pathological pregnancies. |
| | |
Authors:
|
John J Reho; Jennifer Peck; Jacqueline Novak; Rolando J Ramirez |
Related Documents
:
|
10234667 - Uterine blush mimicking a hypervascular tumour in the pelvis as demonstrated by a tripl... 19515407 - Effects of human chorionic gonadotropin on luteal blood flow and progesterone secretion... 15904597 - Temporary, transvaginal occlusion of the uterine arteries: a feasibility and safety study. 7538147 - Identification of nitric oxide synthase in human uterus. 12465657 - Radiation effects on circulating and endothelial cell interactions studied by quantitat... 21039207 - Comparison of the ats versus eu mini wright peak flow meter in normal volunteers. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-16 |
Journal Detail:
|
Title: Hypertension in pregnancy : official journal of the International Society for the Study of Hypertension in Pregnancy Volume: 30 ISSN: 1525-6065 ISO Abbreviation: Hypertens Pregnancy Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-03-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9421297 Medline TA: Hypertens Pregnancy Country: England |
Other Details:
|
Languages: eng Pagination: 208-20 Citation Subset: IM |
Affiliation:
|
Program in Integrated Biosciences, The University of Akron, Akron, OH, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Interprofessional care teams: the role of the healthcare administrator.
Next Document: The risk of intellectual disability in children born to mothers with preeclampsia or eclampsia with ...