Document Detail

Hypertension induced by episodic reductions in uteroplacental blood flow in gravid rat.
MedLine Citation:
PMID:  20846047     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The etiology of preeclampsia remains unclear. Animal modeling of preeclampsia has been useful; however, no model to date represents episodic changes in uteroplacental blood flow that may occur in preeclampsia.
OBJECTIVE: To develop a gravid rat model characterized by episodic reductions in uteroplacental blood flow.
METHOD: Pregnant Sprague Dawley rats were used and subjected to SHAM, reduced uterine perfusion pressure (RUPP), or aortic occlusion on gestational Day 14. Aortic occlusion surgery consisted of implantation of a silastic vascular occluder around the abdominal aorta and silver clips around the uterine-ovarian arteries. Aortic occlusion animals were subjected to five consecutive days of occlusion (40% reduction) each session lasting 1 h. On Day 21, maternal mean arterial pressure (MAP) and fetal morphology were assessed. For isolated blood vessels, resistance-sized mesenteric arteries were harvested and mounted on a pressure arteriograph.
RESULT: Occluder animals experienced a 10 mmHg rise in MAP as compared to SHAM (p < 0.05), and RUPP MAP was significantly increased as compared to control subjects (p < 0.05). Pups from Occluder animals exhibited a decrease in fetal weight as compared to SHAM (p < 0.05), but an increase in fetal weight as compared to RUPP (p < 0.05). Myogenic reactivity of second-order mesenteric arteries increased in Occluder animals as compared to SHAM (p < 0.05), but were similar to that of RUPP.
CONCLUSION: Episodic reductions in uteroplacental blood flow play a crucial role in the altered vascular reactivity seen in Occluder animals and may represent a new model to investigate the mechanisms associated with episodic reductions in uteroplacental blood flow in pathological pregnancies.
John J Reho; Jennifer Peck; Jacqueline Novak; Rolando J Ramirez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-16
Journal Detail:
Title:  Hypertension in pregnancy     Volume:  30     ISSN:  1525-6065     ISO Abbreviation:  Hypertens Pregnancy     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-31     Completed Date:  2011-08-08     Revised Date:  2014-07-23    
Medline Journal Info:
Nlm Unique ID:  9421297     Medline TA:  Hypertens Pregnancy     Country:  England    
Other Details:
Languages:  eng     Pagination:  208-20     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Hypertension, Pregnancy-Induced / etiology*,  physiopathology
Placenta / blood supply*,  physiopathology
Rats, Sprague-Dawley
Regional Blood Flow / physiology*
Uterus / blood supply*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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