| Hypertension and cerebral diffusion tensor imaging in small vessel disease. | |
| | |
MedLine Citation:
|
PMID: 21030696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Hypertension is a risk factor for cerebral small vessel disease, which includes white matter lesions (WML) and lacunar infarcts. These lesions are frequently observed on MRI scans of elderly people and play a role in cognitive decline. Preferably, one would like to evaluate the effect of hypertension before fluid-attenuated inversion recovery visible macrostructural lesions occur, possibly by investigating its effect on the microstructural integrity of the white matter. Diffusion tensor imaging provides measures of structural integrity. METHODS: In 503 patients with small vessel disease, aged between 50 and 85 years, we cross-sectionally studied the relation between blood pressure, hypertension, and hypertension treatment status and diffusion tensor imaging parameters in both normal-appearing white matter (NAWM) and WMLs. All of the subjects underwent 1.5-T MRI and diffusion tensor imaging scanning. Fractional anisotropy and mean diffusivity were calculated in both NAWM and WMLs. RESULTS: Increased blood pressure and hypertension were significantly related to lower fractional anisotropy in both NAWM and WMLs and to higher mean diffusivity in WMLs. For hypertensives, odds ratios for the risk of impaired microstructural integrity (fractional anisotropy) were 3.1 (95% CI: 1.8 to 5.7) and 2.1 (95% CI: 1.2 to 3.5) in NAWM and WMLs, respectively, compared with normotensives. Fractional anisotropy odds ratios for treated uncontrolled subjects were 6.5 (95% CI: 3.3 to 12.7) and 2.7 (95% CI: 1.5 to 5.1) in NAWM and WMLs, respectively, compared with normotensives. CONCLUSIONS: Our data show that diffusion tensor imaging may be an appropriate tool to monitor the effect of blood pressure and the response to treatment on white matter integrity, probably even before the development of WMLs on fluid-attenuated inversion recovery. |
| | |
Authors:
|
Rob A R Gons; Karlijn F de Laat; Anouk G W van Norden; Lucas J B van Oudheusden; Inge W M van Uden; David G Norris; Marcel P Zwiers; Frank-Erik de Leeuw |
Related Documents
:
|
8783776 - Effects of gender and ethnic group on blood pressure control in the elderly. 18005826 - Soft-tissue cephalometric norms in yemeni men. 10523216 - Cardiac and arterial target organ damage in adults with elevated ambulatory and normal ... 9135956 - White coat hypertension in niddm patients with and without incipient and overt diabetic... 14981416 - Left and right ventricular adaptation assessed by doppler tissue echocardiography in at... 3826666 - Respiratory effects of sevoflurane. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-28 |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 41 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-30 Completed Date: 2010-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
|
Languages: eng Pagination: 2801-6 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Donders Institute for Brain, Cognition, and Behaviour, Center for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Anisotropy Antihypertensive Agents / therapeutic use Blood Pressure / physiology Cerebrovascular Disorders / pathology* Cognition Disorders / pathology, psychology Cross-Sectional Studies Diffusion Magnetic Resonance Imaging Drug Resistance Female Humans Hypertension / drug therapy, pathology* Image Processing, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Odds Ratio Risk Factors Smoking / epidemiology |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Management of acute stroke patients with rapidly resolving deficits and persistent vascular occlusio...
Next Document: No-go to tissue plasminogen activator for transient ischemic attack.