Document Detail

Hypertension is associated with increased urinary calcium excretion in patients with nephrolithiasis.
MedLine Citation:
PMID:  20018328     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The epidemiological relationship between nephrolithiasis and hypertension is well-known. Patients with hypertension are at increased risk for nephrolithiasis and those with nephrolithiasis are at risk for hypertension. Urine calcium or urine citrate may be related to hypertension status. We examined the relationship between hypertension and 24-hour urine composition in patients with nephrolithiasis. MATERIALS AND METHODS: We retrospectively reviewed the database on 462 stone forming patients to examine the relationship between hypertension and 24-hour urine composition. Multivariate linear regression models were adjusted for age, race, gender, body mass index, diabetes mellitus and 24-hour urine constituents. Nominal logistic regression was also done to examine the hypertension prevalence by quintile of calcium and citrate excretion. RESULTS: On adjusted multivariate analysis compared with normotensive stone formers those with hypertension excreted 25.6 mg per day more urine calcium, corresponding to a 12% increase in urinary calcium excretion. The relative risk of hypertension was significantly associated with quintile of calcium excretion but not with quintile of citrate excretion (1.29, 95% CI 1.02 to 1.61 vs 0.94, 95% CI 0.78 to 1.14). CONCLUSIONS: In stone formers hypertension was associated only with significantly increased urine calcium. This association is important when treating patients with nephrolithiasis since those with hypertension may require unique dietary and medical therapy.
Brian H Eisner; Sima P Porten; Seth K Bechis; Marshall L Stoller
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Publication Detail:
Type:  Journal Article     Date:  2009-12-16
Journal Detail:
Title:  The Journal of urology     Volume:  183     ISSN:  1527-3792     ISO Abbreviation:  J. Urol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  576-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 American Urological Association. Published by Elsevier Inc. All rights reserved.
Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
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MeSH Terms
Calcium / urine*
Hypertension / complications*
Middle Aged
Nephrolithiasis / complications*,  urine*
Retrospective Studies
Reg. No./Substance:

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