Document Detail

Hypersplenism and splenectomy in lymphoproliferative and myeloproliferative disorders.
MedLine Citation:
PMID:  3830529     Owner:  NLM     Status:  MEDLINE    
Splenic pooling of red cells and an expanded plasma volume are considered to be among the major mechanisms responsible for the anaemia in hypersplenism. In those conditions in which massive splenomegaly is associated with various degrees of marrow failure, diagnosis of the cause of anaemia may be difficult. A simple technique was used to estimate the degree of hypersplenism, from red cell mass data, in 94 patients with unequivocal lymphoproliferative or myeloproliferative disorders. The splenic effect was found to correlate well with both the size of the spleen (r = 0.75-0.90) and the actual red cell mass (0.79), and was abolished by splenectomy. Clinical data is also presented on 43 of these patients who underwent splenectomy. The incidence and type of complications, survival figures, and possible criteria for patient selection are discussed.
P J Kesteven; J M Pullan; U H Glass; G Wetherley-Mein
Related Documents :
21278619 - Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and pr...
19413729 - Delayed hemolytic transfusion reaction in sickle cell disease patients: evidence of an ...
8122949 - Acute chest syndrome in adult afro-caribbean patients with sickle cell disease. analysi...
19657839 - Thalassemia trait in outpatient clinics of sana'a city, yemen.
7258239 - The efficacy of type and screen to reduce unnecessary cross matches for obstetric patie...
15025289 - Study of haemoglobin s percentage and haematological parameters in sickle cell trait.
6767199 - Mannitol absorption and excretion in uremic patients regularly treated with gastrointes...
8554739 - Immunopathogenic mechanisms in hypertension.
1629 - Polyarthritis, polyarteritis and hepatitis b.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and laboratory haematology     Volume:  7     ISSN:  0141-9854     ISO Abbreviation:  Clin Lab Haematol     Publication Date:  1985  
Date Detail:
Created Date:  1986-05-07     Completed Date:  1986-05-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907061     Medline TA:  Clin Lab Haematol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  297-306     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Volume
Erythrocytes / pathology
Hypersplenism / complications*,  etiology,  surgery
Lymphoproliferative Disorders / complications*
Middle Aged
Myeloproliferative Disorders / complications*
Polycythemia / complications
Spleen / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Are hip osteoarthritis and carcinomatous metastasis mutually exclusive?
Next Document:  C-reactive protein levels in neutropenic patients with pyrexia.