| Hyperspectral imaging in diabetic foot wound care. | |
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MedLine Citation:
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PMID: 20920429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diabetic foot ulceration is a major complication of diabetes and afflicts as many as 15 to 25% of type 1 and 2 diabetes patients during their lifetime. If untreated, diabetic foot ulcers may become infected and require total or partial amputation of the affected limb. Early identification of tissue at risk of ulcerating could enable proper preventive care, thereby reducing the incidence of foot ulceration. Furthermore, noninvasive assessment of tissue viability around already formed ulcers could inform the diabetes caregiver about the severity of the wound and help assess the need for amputation. This article reviews how hyperspectral imaging between 450 and 700 nm can be used to assess the risk of diabetic foot ulcer development and to predict the likelihood of healing noninvasively. Two methods are described to analyze the in vivo hyperspectral measurements. The first method is based on the modified Beer-Lambert law and produces a map of oxyhemoglobin and deoxyhemoglobin concentrations in the dermis of the foot. The second is based on a two-layer optical model of skin and can retrieve not only oxyhemoglobin and deoxyhemoglobin concentrations but also epidermal thickness and melanin concentration along with skin scattering properties. It can detect changes in the diabetic foot and help predict and understand ulceration mechanisms. |
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Authors:
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Dmitry Yudovsky; Aksone Nouvong; Laurent Pilon |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-09-01 |
Journal Detail:
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Title: Journal of diabetes science and technology Volume: 4 ISSN: 1932-2968 ISO Abbreviation: J Diabetes Sci Technol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-10-05 Completed Date: 2011-02-10 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 101306166 Medline TA: J Diabetes Sci Technol Country: United States |
Other Details:
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Languages: eng Pagination: 1099-113 Citation Subset: IM |
Copyright Information:
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© 2010 Diabetes Technology Society. |
Affiliation:
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Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Gas Monitoring, Transcutaneous
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methods* Diabetic Foot / diagnosis, metabolism, physiopathology* Diagnostic Imaging / methods Hemoglobins / metabolism Humans Oxyhemoglobins / metabolism Skin / metabolism Spectrum Analysis / methods* Wound Healing / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R42-DK069871/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins; 9008-02-0/deoxyhemoglobin |
| Comments/Corrections | |
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