Document Detail

Hypersexuality with antiparkinsonian therapy.
MedLine Citation:
PMID:  2575449     Owner:  NLM     Status:  MEDLINE    
Thirteen parkinsonian patients drawn from two large parkinsonism clinics experienced hypersexuality as a consequence of anti-parkinsonian therapy. The cases include only those whose sexual behavior on treatment became a concern to the patient's family or a social agency. The majority of patients were men and had a relatively early onset of parkinsonian symptomatology. There was no relation between functional improvement and increased sexuality. Most patients showed some element of dose dependency between antiparkinsonian drugs and the hypersexual behavior. Prior sexual profile included from no sexual outlet to hypersexuality. Neither the prior history of psychiatric illness nor brain damage predisposed to such response on treatment, and in most patients, it was not a part of hypomania or a more diffuse psychiatric disturbance. We propose that hypersexuality on antiparkinsonian drugs is consequent to inhibition of prolactin secretion.
R J Uitti; C M Tanner; A H Rajput; C G Goetz; H L Klawans; B Thiessen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  12     ISSN:  0362-5664     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-03-13     Completed Date:  1990-03-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  375-83     Citation Subset:  IM    
Department of Neurology, Mayo Clinic, Rochester, Minnesota.
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MeSH Terms
Age Factors
Amantadine / adverse effects,  therapeutic use
Dopamine Agents / adverse effects*,  therapeutic use
Levodopa / adverse effects*,  therapeutic use
Middle Aged
Parkinson Disease / drug therapy*
Phenethylamines / adverse effects*
Selegiline / adverse effects*,  therapeutic use
Sex Factors
Sexual Behavior / drug effects*
Reg. No./Substance:
0/Dopamine Agents; 0/Levodopa; 0/Phenethylamines; 14611-51-9/Selegiline; 768-94-5/Amantadine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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