Document Detail

Hypersensitivity to preservatives.
MedLine Citation:
PMID:  15186371     Owner:  NLM     Status:  MEDLINE    
Preservatives are biocidal chemicals added to cosmetics, topical medicaments, consumer goods, foods, and industrial products to protect them against microbial spoilage and to protect the consumer against infection. The ideal preservative, both effective and devoid of irritant or sensitizing potential, is still to be discovered. The present paper reviews the most important classes of preservatives, namely parabens, formaldehyde-releasers, and isothiazolinones. The author also discusses newer agents such as Euxyl K 400 and isopropynyl butylcarbamate. Each preservative is described in terms of chemical and physical characteristics, antimicrobial efficacy, exposure, cutaneous adverse reactions, patch testing concentrations, patterns of cross-reactions, and reported rates of sensitization. The history of preservatives goes back to the 1930s, and ironically, the parabens, which the industry has sought to replace with "safer" alternatives, are still the most frequently used biocides in cosmetics and appear to be far less sensitizing than most of the newer agents.
Denis Sasseville
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Dermatologic therapy     Volume:  17     ISSN:  1396-0296     ISO Abbreviation:  Dermatol Ther     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-09     Completed Date:  2004-09-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9700070     Medline TA:  Dermatol Ther     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  251-63     Citation Subset:  IM    
Division of Dermatology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Carbamates / adverse effects,  immunology
Cosmetics / adverse effects
Formaldehyde / adverse effects,  immunology
Hypersensitivity / diagnosis,  epidemiology,  immunology*
Nitriles / adverse effects,  immunology
Parabens / adverse effects
Preservatives, Pharmaceutical / adverse effects*
Thiazoles / adverse effects,  immunology
Reg. No./Substance:
0/Carbamates; 0/Cosmetics; 0/Nitriles; 0/Parabens; 0/Preservatives, Pharmaceutical; 0/Thiazoles; 35691-65-7/1,2-dibromo-2,4-dicyanobutane; 50-00-0/Formaldehyde; 55406-53-6/3-iodo-2-propynylbutylcarbamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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