Document Detail

Hypersensitivity to glucocorticoids: does it exist?
MedLine Citation:
PMID:  8731243     Owner:  NLM     Status:  MEDLINE    
Hypersensitivity to corticosteroids is a classical but rarely reported event. We report a 30-year-old patient who developed generalized urticaria after her first methylprednisolone bolus. We reviewed the relevant literature to look for factors associated with hypersensitivity to corticosteroids. Causality should be evaluated on a case-by-case basis using diagnostic criteria for drug hypersensitivity reaction. Etiopathogenesis may involve either an IgE-mediated immunoallergic reaction or semi-delayed hypersensitivity. The main problems are identification of the offending agent and evaluation of the safety of further corticosteroid therapy. Although a few fatal reactions have been reported, some were probably due to underlying cardiovascular disease or serum electrolyte abnormalities.
P Pizzuti; F Lioté; I Cerf-Payrastre; A Dryll
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Revue du rhumatisme (English ed.)     Volume:  63     ISSN:  1169-8446     ISO Abbreviation:  Rev Rhum Engl Ed     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-10-29     Completed Date:  1996-10-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9313916     Medline TA:  Rev Rhum Engl Ed     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  IM    
Rheumatology Department (Viggo Petersen Center), Lariboisière Teaching Hospital, Paris, France.
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MeSH Terms
Arthritis, Rheumatoid / drug therapy
Drug Eruptions / etiology*,  immunology,  physiopathology
Drug Hypersensitivity
Glucocorticoids / administration & dosage,  adverse effects*,  therapeutic use
Injections, Intravenous
Methylprednisolone / administration & dosage,  adverse effects*,  therapeutic use
Reg. No./Substance:
0/Glucocorticoids; 83-43-2/Methylprednisolone

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