| Hypersensitivity to antigen derived from brain tissue in patients with Huntington's disease and in individuals at risk. | |
| | |
MedLine Citation:
|
PMID: 6234326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The hypothesis that an immune response is directed to components of brain tissue in Huntington's disease (HD) was examined. 27 patients with HD, 21 children of affected parents who showed no signs of disease, 6 spouses of HD patients, and 40 patients with other neurologic diseases were investigated. Leukocyte migration inhibition to antigens prepared from brain tissue was demonstrated in 26 HD patients and in 9 children. None of the six spouses reacted. 13 patients with other neurologic conditions (including 60% of patients after cerebrovascular accidents) reacted to rat brain extract. Fractionation of brain tissue indicated that the material responsible for reactions in these patients differed from that in HD. The material that elicited hypersensitivity in HD was not species specific, since it was found in rat, calf, human, and rabbit brain. It was not present in rat kidney, liver, or heart. Preliminary characterization showed that the material was protein in nature, contained sugar and lipid, and was heat labile. The finding of hypersensitivity in about half the unaffected children of HD parents suggests that it may precede the clinical onset of disease and serve as a marker for the gene. |
| | |
Authors:
|
R S Walls; A Ruwoldt |
Related Documents
:
|
19946236 - Structural changes in carotid arteries and impairment of fibrinolysis in hemodialyzed a... 8396696 - The significance of serum levels of soluble 60kda receptors for tumor necrosis factor i... 18401156 - Correlations of sialic acid with markers of inflammation, atherosclerosis and cardiovas... 17556836 - Anorexia in hemodialysis patients: the possible role of des-acyl ghrelin. 8858696 - Confusional migraine in childhood. 20854966 - Relation of level of b-type natriuretic peptide with outcomes in patients with infectiv... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of clinical investigation Volume: 74 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1984 Jul |
Date Detail:
|
Created Date: 1984-07-31 Completed Date: 1984-07-31 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 165-72 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Animals Antigens / isolation & purification* Brain / immunology* Cell Migration Inhibition* Female Humans Huntington Disease / immunology* Leukocytes / immunology* Male Middle Aged Nervous System Diseases / immunology* Rats Reference Values Serum Albumin, Bovine / immunology Species Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Antigens; 0/Serum Albumin, Bovine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Selective IgA deficiency: analysis of Ig production in vitro.
Next Document: DNA-anti-DNA immune complexes. Antibody protection of a discrete DNA fragment from DNase digestion i...