Document Detail

Hypersensitivity to acute ANG II in female growth-restricted offspring is exacerbated by ovariectomy.
MedLine Citation:
PMID:  21832208     Owner:  NLM     Status:  MEDLINE    
Female growth-restricted offspring are normotensive in adulthood. However, ovariectomy induces a marked increase in mean arterial pressure (MAP) that is abolished by renin angiotensin system (RAS) blockade, suggesting RAS involvement in the etiology of hypertension induced by ovariectomy in adult female growth-restricted offspring. Blockade of the RAS also abolishes hypertension in adult male growth-restricted offspring. Moreover, sensitivity to acute ANG II is enhanced in male growth-restricted offspring. Thus, we hypothesized that an enhanced sensitivity to acute ANG II may contribute to hypertension induced by ovariectomy in female growth-restricted offspring. Female offspring were subjected to ovariectomy (OVX) or sham ovariectomy (intact) at 10 wk of age. Cardio-renal hemodynamic parameters were determined before and after an acute infusion of ANG II (100 ng·kg(-1)·min(-1) for 30 min) at 16 wk of age in female offspring pretreated with enalapril (40 mg·kg(-1)·day(-1) for 7 days). Acute ANG II induced a significant increase in MAP in intact growth-restricted offspring (155 ± 2 mmHg, P < 0.05) relative to intact control (145 ± 4 mmHg). Ovariectomy augmented the pressor response to ANG II in growth-restricted offspring (163 ± 2 mmHg, P < 0.05), with no effect in control (142 ± 2 mmHg). Acute pressor responses to phenylephrine did not differ in growth-restricted offspring relative to control, intact, or ovariectomized. Furthermore, renal hemodynamic responses to acute ANG II were significantly enhanced only in ovariectomized female growth-restricted offspring. Thus, these data suggest that enhanced responsiveness to acute ANG II is programmed by intrauterine growth restriction and that sensitivity to acute ANG II is modulated by ovarian hormones in female growth-restricted offspring.
Norma B Ojeda; Suttira Intapad; Thomas P Royals; Joshua T Black; John Henry Dasinger; F Lee Tull; Barbara T Alexander
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-10
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  301     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-07     Completed Date:  2011-12-06     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1199-205     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / pharmacology*
Animals, Newborn / growth & development*,  physiology*
Antihypertensive Agents / pharmacology
Blood Pressure / drug effects*,  physiology
Body Weight / physiology
Enalapril / pharmacology
Fetal Growth Retardation / physiopathology*
Models, Animal
Phenylephrine / pharmacology
Rats, Sprague-Dawley
Renin-Angiotensin System / drug effects,  physiology
Sex Characteristics
Vasoconstrictor Agents / pharmacology
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents; 0/Vasoconstrictor Agents; 11128-99-7/Angiotensin II; 1WS297W6MV/Phenylephrine; 69PN84IO1A/Enalapril

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