Document Detail

Hypersensitivity to acetate dialysate: report of a case.
MedLine Citation:
PMID:  1683377     Owner:  NLM     Status:  MEDLINE    
Acetate dialysate is currently the most widely used in hemodialysis. The adverse effect of acetate during hemodialysis is well known upon the cardiovascular system. However, hypersensitivity reactions related to acetate during dialysis therapy are rare. We report a patient who developed hypersensitivity reactions such as generalized skin itching, flushing, hypotension and shortness of breath within a few minutes of beginning hemodialysis with acetate dialysate. Changing dialyzer membranes failed to alleviate these symptoms. Using the same dialyzer and tubing, these reactions disappeared immediately when bicarbonate dialysate was substituted for acetate dialysate. The patient's serum IgE and total eosinophile counts were normal. We conclude that acetate may initiate hypersensitivity reactions during hemodialysis. The exact mechanism is still unclear.
C S Yang; C J Liu; S H Lee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  90     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-12-30     Completed Date:  1991-12-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  TAIWAN    
Other Details:
Languages:  eng     Pagination:  800-2     Citation Subset:  IM    
Department of Internal Medicine, Cathay General Hospital, Taipei, Taiwan R.O.C.
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MeSH Terms
Acetates / adverse effects*
Drug Hypersensitivity / etiology*
Middle Aged
Renal Dialysis / adverse effects*
Reg. No./Substance:

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