Document Detail


Hypersensitivity reactions to food additives.
MedLine Citation:
PMID:  19390435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To provide an updated concise review on food additives adverse reactions, diagnosis, and management. RECENT FINDINGS: Despite the common use of food additives, their adverse reactions seem to be very rare in the general population (0.01-0.23%) but higher in atopic individuals (2-7%). Probably because of the difficulty in diagnosis, most of the available information is based on case reports or small series. Reported reactions are mostly mild and may affect the skin, the gastrointestinal tract, or the airways, and rarely anaphylaxis. SUMMARY: Food additives should be suspected as the culprit in patients who report a history of reactions to a number of unrelated foods or to a certain food when commercially prepared but not when prepared at home. The major problem in dealing with reactions to additives is the identification of the offending agent(s). Apart from a careful history taking, allergy skin testing or in-vitro testing are rarely useful. Trials of elimination and reintroduction may be more helpful. If the anticipated reaction is severe, a well designed challenge testing should be carried out. Once the offending additive(s) is confirmed, treatment is avoidance. Because accidental exposure often happens, patients with a history of severe reactions should have self-injectable epinephrine and wear MedicAlert (Turlock, California, USA) identification.
Authors:
Shahid Randhawa; Sami L Bahna
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in allergy and clinical immunology     Volume:  9     ISSN:  1473-6322     ISO Abbreviation:  Curr Opin Allergy Clin Immunol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-20     Completed Date:  2009-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100936359     Medline TA:  Curr Opin Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  278-83     Citation Subset:  IM    
Affiliation:
Allergy and Immunology Section, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130-3932, USA.
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MeSH Terms
Descriptor/Qualifier:
Allergens / adverse effects*
Bronchodilator Agents / administration & dosage
Epinephrine / administration & dosage
Food Additives / adverse effects*,  chemistry,  classification
Food Hypersensitivity / diagnosis*,  epidemiology,  immunology,  therapy*
Food Labeling
Humans
Hypersensitivity
Chemical
Reg. No./Substance:
0/Allergens; 0/Bronchodilator Agents; 0/Food Additives; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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