Document Detail

Hypersensitivity myocarditis complicating hypertrophic cardiomyopathy heart.
MedLine Citation:
PMID:  15266362     Owner:  NLM     Status:  MEDLINE    
The present report describes a case of eosinophilic myocarditis complicating hypertrophic cardiomyopathy. The 47-year-old female patient, known to have hypertrophic cardiomyopathy, was admitted with biventricular failure and managed aggressively with dobutamine infusion and other drugs while being assessed for heart transplantation. On transthoracic echocardiogram, she had moderate left ventricular dysfunction with regional variability and moderate mitral regurgitation. The recipient's heart showed the features of apical hypertrophic cardiomyopathy and myocarditis with abundant eosinophils. Myocarditis is rare and eosinophilic myocarditis is rarer. It is likely that the hypersensitivity (eosinophilic) myocarditis was related to dobutamine infusion therapy. Eosinophilic myocarditis has been reported with an incidence of 2.4% to 7.2% in explanted hearts and may be related to multidrug therapy.
Jagdish Butany; Vidhya Nair; Manmeet S Ahluwalia; James Graba; Dina El Demellawy; Vivek Rao; Heather Ross
Publication Detail:
Type:  Case Reports; Editorial    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  20     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-07-21     Completed Date:  2004-09-17     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  911-4     Citation Subset:  IM    
Department of Pathology, Toronto General Hospital, Toronto, Ontario.
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MeSH Terms
Adrenergic beta-Agonists / adverse effects
Cardiomyopathy, Hypertrophic / drug therapy*,  physiopathology,  ultrasonography
Dobutamine / adverse effects
Drug Hypersensitivity*
Heart Failure / drug therapy,  physiopathology,  ultrasonography
Middle Aged
Mitral Valve Insufficiency / drug therapy,  physiopathology,  ultrasonography
Myocarditis / chemically induced*,  physiopathology,  ultrasonography
Myocardium / pathology
Stroke Volume / physiology
Ventricular Dysfunction, Left / drug therapy,  physiopathology,  ultrasonography
Reg. No./Substance:
0/Adrenergic beta-Agonists; 34368-04-2/Dobutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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