| Hypersensitivity Testing for Aspergillus fumigatus IgE Is Significantly More Sensitive Than Testing for Aspergillus niger IgE. | |
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MedLine Citation:
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PMID: 22261444 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We sought to determine if sufficient redundancy exists between specific IgE testing for Aspergillus fumigatus and Aspergillus niger to eliminate one of the assays in determining Aspergillus hypersensitivity. We reviewed regional laboratory results comparing A fumigatus-specific IgE with A niger-specific IgE using the Pharmacia UniCAP system (Pharmacia, Kalamazoo, MI). By using the Fisher exact test as an index of concordance among paired results, we showed a significant difference between 109 paired samples for the presence of specific IgE to A fumigatus and A niger (P < .0001). Of these specimens, 94 were negative for IgE to both species, 10 were positive for A fumigatus and negative for A niger; no specimen was positive for A niger and negative for A fumigatus. We conclude that A fumigatus-specific IgE is sufficient to detect Aspergillus hypersensitivity. The assay for A niger-specific IgE is redundant, less sensitive, and unnecessary if the assay for specific IgE for A fumigatus is performed. |
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Authors:
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Thomas A Selvaggi; Jeremy P Walco; Sujal Parikh; Gary A Walco |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 137 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 203-6 Citation Subset: AIM; IM |
Affiliation:
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Special Diagnostic Immunology Laboratory, Dept of Medicine, Hackensack University Medical Center, 30 Prospect Ave Rm 1936, Hackensack, NJ 07601. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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