Document Detail

Hyperresponsiveness of cardiac muscles to histamine in reserpine-treated guinea pigs.
MedLine Citation:
PMID:  7830330     Owner:  NLM     Status:  MEDLINE    
The hyperresponsiveness of cardiac tissue to histamine following treatment with reserpine was pharmacologically characterized. Guinea pig hearts were isolated 24 hours after intraperitoneal administration of 5 mg/kg reserpine. This treatment resulted in a complete depletion of tissue norepinephrine. Reserpine treatment potentiated the positive inotropic response of isolated perfused hearts to histamine at doses ranging from 0.3 to 3 micrograms (23 to 57% increase for reserpine-treated animals vs. 14 to 32% increase for control animals). Isolated left ventricular papillary muscle of reserpine-treated guinea pig hearts also showed hyperresponsiveness to histamine at concentrations of 0.1 microM or greater. The hyperresponsiveness of the papillary muscle contraction of the reserpine-treated animals to histamine was abolished in the presence of 1 microM cimetidine, but not attenuated in the presence of 1 microM diphenhydramine. This hyperresponsiveness was not modified by 1 microM bunazosin or 1 microM propranolol. The results suggest that H2-receptor mediated action plays a role in the hyperresponsiveness of cardiac muscles to histamine.
N Okazaki; K Tanonaka; Y Nasa; N Takagi; T Yamasaki; S Yoshida; S Takeo
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  35     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-02-22     Completed Date:  1995-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  661-71     Citation Subset:  IM    
Department of Pharmacology, Tokyo College of Pharmacy, Hachioji, Japan.
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MeSH Terms
Drug Synergism
Guinea Pigs
Heart Rate / drug effects
Histamine / pharmacology*
Myocardial Contraction / drug effects*
Myocardium / metabolism
Norepinephrine / metabolism
Papillary Muscles / drug effects*
Receptors, Histamine / drug effects
Reserpine / pharmacology*
Reg. No./Substance:
0/Receptors, Histamine; 50-55-5/Reserpine; 51-41-2/Norepinephrine; 51-45-6/Histamine

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