Document Detail

Hyperresistinemia is associated with coexistence of hypertension and type 2 diabetes.
MedLine Citation:
PMID:  18180399     Owner:  NLM     Status:  MEDLINE    
Numerous studies have demonstrated that high blood pressure substantially increases the risk of microvascular and macrovascular complications in patients with type 2 diabetes mellitus (T2DM). Currently, we found that serum resistin, an adipocyte- and monocyte-derived cytokine, was positively correlated with several components of the metabolic syndrome, including hypertension in T2DM. To investigate the association of resistin with an etiologic difference among subjects with hypertension with T2DM, hypertension without T2DM, and normotensive T2DM, we analyzed 210 subjects, including 91 with hypertension with T2DM, 55 with hypertension without T2DM, and 64 with normotensive T2DM. Serum resistin level was higher in subjects with hypertension with T2DM, followed by subjects with normotensive T2DM and hypertension without T2DM, irrespective of antihypertensive treatment status (20.9+/-17.6 and 14.0+/-8.9 versus 11.2+/-7.6 ng/mL, respectively; P<0.01). Simple regression analysis revealed that resistin positively correlated with blood pressure (systolic blood pressure: r=0.29, P<0.01; diastolic blood pressure: r=0.21, P<0.05) and intima-media thickness (r=0.27; P<0.05) in patients with T2DM but not in subjects with hypertension without T2DM. Multiple regression analysis, adjusted for age, gender, body mass index, fasting glucose, high-density lipoprotein cholesterol, white blood cell counts, and glomerular filtration rate, further revealed that resistin was an independent factor for high blood pressure in patients with T2DM (P<0.05). In vitro gene expression analysis in human coronary endothelial cells revealed that resistin induced fatty acid binding protein, a key molecule of insulin resistance, diabetes, and atherosclerosis. These results suggest that hyperresistinemia would contribute to the pathogenesis of hypertension in patients with T2DM, significantly linked to vascular complications and cardiovascular events.
Yasunori Takata; Haruhiko Osawa; Mie Kurata; Maki Kurokawa; Junko Yamauchi; Masaaki Ochi; Wataru Nishida; Takafumi Okura; Jitsuo Higaki; Hideichi Makino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-07
Journal Detail:
Title:  Hypertension     Volume:  51     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-02-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  534-9     Citation Subset:  IM    
Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan.
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MeSH Terms
Blood Pressure
Cells, Cultured
Coronary Vessels / metabolism
Diabetes Mellitus, Type 2 / blood*,  complications*
Diabetic Angiopathies / etiology
Endothelial Cells / metabolism
Fatty Acid-Binding Proteins / genetics,  metabolism
Gene Expression / drug effects
Hypertension / etiology*,  physiopathology
Middle Aged
Recombinant Proteins / pharmacology
Resistin / blood*,  pharmacology
Risk Factors
Reg. No./Substance:
0/Fatty Acid-Binding Proteins; 0/Recombinant Proteins; 0/Resistin

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