| Hyperreninemia and secondary hyperaldosteronism in a patient with pheochromocytoma and von Hippel-Lindau disease. | |
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MedLine Citation:
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PMID: 1436350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a 21-year-old Caucasian women with von Hippel-Lindau disease, norepinephrine-producing adrenal pheochromocytoma was identified as the underlying cause of severe hypertension. She was found to have extremely elevated levels of circulating renin and aldosterone, and she was markedly hypokalemic. Administration of captopril further enhanced renin secretion, while her blood pressure improved. The patient became normokalemic following tumor removal, and her blood pressure decreased to normal levels with reestablishment of normal circadian blood pressure rhythm. This case demonstrates that, in the absence of renovascular or malignant hypertension, pheochromocytoma can be the underlying cause for the clinical syndrome of hypertension associated with severe hypokalemia and hyperreninemic hyperaldosteronism. |
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Authors:
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T Lenz; H M Thiede; J Nussberger; S A Atlas; A Distler; K L Schulte |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Nephron Volume: 62 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1992 |
Date Detail:
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Created Date: 1992-12-04 Completed Date: 1992-12-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 345-50 Citation Subset: IM |
Affiliation:
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Department of Medicine, Klinikum Steglitz, Free University of Berlin, FRG. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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complications* Adult Captopril / diagnostic use Catecholamines / blood Clonidine / diagnostic use Female Humans Hyperaldosteronism / complications* Hypertension / drug therapy Pheochromocytoma / complications* Renin / blood* von Hippel-Lindau Disease / complications*, genetics |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 4205-90-7/Clonidine; 62571-86-2/Captopril; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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