| Hyperrenin-hyperaldosterone-dependent malignant hypertension in polyarteritis nodosa. | |
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MedLine Citation:
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PMID: 7903825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have described a patient, subsequently found to have polyarteritis, whose renin activity was 60 times normal, a level associated with malignant hypertension and severe renal artery stenosis. The severe hypertension and its resistance to multiple medications in the face of a dramatic response to low-dose enalapril imply the renin-angiotensin system was the primary pathophysiologic mechanism. We believe renin activity should be measured in hypertensive patients with polyarteritis. Furthermore, PAN should be in the differential diagnosis of hyperreninemic hypertension. ACE inhibitors should be strongly considered in the management of classical PAN-induced hypertension. |
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Authors:
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M C Thel; R B Mannon; N B Allen |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Southern medical journal Volume: 86 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-02-02 Completed Date: 1994-02-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1400-2 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood Humans Hypertension, Malignant / blood, etiology* Hypertension, Renal / blood, etiology Male Polyarteritis Nodosa / complications*, diagnosis Renin / blood |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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