Document Detail

Hyperrenin-hyperaldosterone-dependent malignant hypertension in polyarteritis nodosa.
MedLine Citation:
PMID:  7903825     Owner:  NLM     Status:  MEDLINE    
We have described a patient, subsequently found to have polyarteritis, whose renin activity was 60 times normal, a level associated with malignant hypertension and severe renal artery stenosis. The severe hypertension and its resistance to multiple medications in the face of a dramatic response to low-dose enalapril imply the renin-angiotensin system was the primary pathophysiologic mechanism. We believe renin activity should be measured in hypertensive patients with polyarteritis. Furthermore, PAN should be in the differential diagnosis of hyperreninemic hypertension. ACE inhibitors should be strongly considered in the management of classical PAN-induced hypertension.
M C Thel; R B Mannon; N B Allen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  86     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-02-02     Completed Date:  1994-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1400-2     Citation Subset:  AIM; IM    
Department of Internal Medicine, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Aldosterone / blood
Hypertension, Malignant / blood,  etiology*
Hypertension, Renal / blood,  etiology
Polyarteritis Nodosa / complications*,  diagnosis
Renin / blood
Reg. No./Substance:
52-39-1/Aldosterone; EC

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