Document Detail

Hyperreactive malarial splenomegaly in expatriates.
MedLine Citation:
PMID:  17161315     Owner:  NLM     Status:  MEDLINE    
Hyperreactive malarial splenomegaly, one of the major causes of splenomegaly in tropics, has been often reported in expatriates of non-tropical settings. Essential features are recurrent malarial infection, overproduction of IgM and hyperplasia of lymphoreticular system. The practice of diagnosing the condition by exclusion of obvious causes of splenomegaly in the tropics has been abandoned. There are specific criteria for the diagnosis. Huge splenomegaly >10 cm below costal margin, serum IgM more than 2 x standard deviation (2SD) above the local mean, high titre of malarial antibodies and response to antimalarial drugs are the cornerstones of the diagnosis. Splenic lymphoma with villous lymphocytes coexists with this condition and it should always be considered in the differential diagnosis of unresponsive or poorly responsive cases of hyperreactive malarial splenomegaly. Condition with fever and acute haemolysis in HMS has been termed as Fulminant tropical splenomegaly syndrome. Treatment of the condition depends on antimalarial (chloroquine/ proguanil/ pyrimethamine) chemoprophylaxis for 1 year or more.
Ranjan K Singh
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-18
Journal Detail:
Title:  Travel medicine and infectious disease     Volume:  5     ISSN:  1477-8939     ISO Abbreviation:  Travel Med Infect Dis     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-03-20     Revised Date:  2009-10-21    
Medline Journal Info:
Nlm Unique ID:  101230758     Medline TA:  Travel Med Infect Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  24-9     Citation Subset:  IM    
District Hospital Daltonganj, Jharkhand, India.
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MeSH Terms
Antibodies, Protozoan / blood
Antimalarials / therapeutic use*
Diagnosis, Differential
Immunoglobulin M / blood
Malaria / complications*,  drug therapy,  immunology*
Splenomegaly / etiology*,  immunology,  surgery
Treatment Outcome
Tropical Climate
Reg. No./Substance:
0/Antibodies, Protozoan; 0/Antimalarials; 0/Immunoglobulin M

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