| Hyperproliferation of BXSB B cells is linked to the Yaa allele. | |
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MedLine Citation:
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PMID: 8906745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systemic lupus erythematosus is characterized by polyclonal B cell activation, the production of autoantibodies, and often by renal disease. Previous studies demonstrated that unfractionated B cells from several strains of mice with lupus hyperproliferate in culture when stimulated with lipopolysaccharide (LPS) or anti-IgM. We wished to further examine proliferation of resting B cells from the BXSB mouse model of lupus and mice with the Yaa allele, when activated with a number of stimuli. Our work demonstrates that: (1) resting B cells from mice containing the Yaa allele hyperproliferated compared to that seen with B cells from mice lacking the Yaa allele, (2) this hyperproliferation occurred whether cells were stimulated with phorbol myristate acetate/ionomycin, LPS, anti-IgM, or CD40L cross-linking, (3) this hyperproliferation is specific to B and not T cells. Taken together these data suggest that one mechanism by which the Yaa allele contributes to the accelerated onset of lupus in BXSB male mice is through its influence on B cell activation. |
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Authors:
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L E DesJardin; E J Butfiloski; E S Sobel; J Schiffenbauer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Clinical immunology and immunopathology Volume: 81 ISSN: 0090-1229 ISO Abbreviation: Clin. Immunol. Immunopathol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-01-02 Completed Date: 1997-01-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0356637 Medline TA: Clin Immunol Immunopathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 145-52 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Florida College of Medicine, Gainesville 32610, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Animals Antibodies, Anti-Idiotypic / pharmacology B-Lymphocytes / immunology* Disease Models, Animal Immunoglobulin M / immunology Ionomycin / pharmacology Linkage (Genetics) Lipopolysaccharides / pharmacology Lupus Erythematosus, Systemic / genetics, immunology, pathology Lymphocyte Activation / genetics Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Spleen / cytology Tetradecanoylphorbol Acetate / pharmacology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI-27324/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anti-Idiotypic; 0/Immunoglobulin M; 0/Lipopolysaccharides; 0/anti-IgM; 16561-29-8/Tetradecanoylphorbol Acetate; 56092-81-0/Ionomycin |
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