| Hyperprolactinemia associated with psychotropics--a review. | |
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MedLine Citation:
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PMID: 20521318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Different classes of psychotropics can cause hyperprolactinemia to varying degrees. Among antipsychotics, typical agents and risperidone are the most frequent and significant offenders. In this review we discuss the pathophysiology, offending medications, assessment and management of hyperprolactinemia. METHODS: We did a literature review between 1976 and 2008 using PubMed, MEDLINE, PsychINFO and Cochrane database. Search terms used were prolactin, hyperprolactinemia, psychotropics, antipsychotics, typical antipsychotics, atypical antipsychotics, antidepressants and SSRIs. RESULTS: Prolactin elevation is more common with antipsychotics than with other classes of drugs. Typical antipsychotics are more prone to cause hyperprolactinemia than atypical agents. Management options include discontinuation of offending medication, switching to another psychotropic, supplementing concurrent hormonal deficiencies and adding a dopamine agonist or aripiprazole. CONCLUSION: Clinicians need to be alert about the potential for hyperprolactinemia and its manifestations with these medications. Prolactin levels need to be monitored and other causes of hyperprolactinemia ruled out in suspected cases. |
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Authors:
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Subramoniam Madhusoodanan; Suprit Parida; Carolina Jimenez |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Human psychopharmacology Volume: 25 ISSN: 1099-1077 ISO Abbreviation: Hum Psychopharmacol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-03 Completed Date: 2010-09-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8702539 Medline TA: Hum Psychopharmacol Country: England |
Other Details:
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Languages: eng Pagination: 281-97 Citation Subset: IM |
Affiliation:
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St. John's Episcopal Hospital, Rockaway, New York 11691, USA. sdanan@ehs.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Anxiety Agents / adverse effects, therapeutic use Antidepressive Agents / adverse effects, therapeutic use Antipsychotic Agents / adverse effects, therapeutic use Female Humans Hyperprolactinemia / chemically induced*, drug therapy, epidemiology, metabolism Male Mental Disorders / drug therapy Prolactin / blood, physiology Psychotropic Drugs / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Antidepressive Agents; 0/Antipsychotic Agents; 0/Psychotropic Drugs; 9002-62-4/Prolactin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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