Document Detail

MedLine Citation:
PMID:  17889620     Owner:  NLM     Status:  MEDLINE    
Hyperprolactinaemia is a frequent cause of reproductive problems encountered in clinical practice. A variety of pathophysiological conditions can lead to hyperprolactinaemia; therefore, pregnancy, drug effects, hypothyroidism and polycystic ovary syndrome should be excluded before investigating for prolactin-secreting pituitary tumours. Prolactinomas are mainly diagnosed in women aged 20-40 years. They present with clinical features of hyperprolactinaemia (galactorrhoea, gonadal dysfunction), and more rarely with large tumours, headache and visual field loss due to optic chiasm compression. Medical therapy with dopamine agonists is the treatment of choice for both micro- and macroprolactinomas. Tumour shrinkage and restoration of gonadal function are achieved in the majority of cases with dopamine agonists. A trial of withdrawal of medical therapy may be considered in many patients with close follow-up. Pituitary surgery and radiotherapy currently have very limited indications. Pregnancies in patients with prolactinomas need careful planning and close monitoring.
V K B Prabhakar; J R E Davis
Publication Detail:
Type:  Journal Article; Review     Date:  2007-09-21
Journal Detail:
Title:  Best practice & research. Clinical obstetrics & gynaecology     Volume:  22     ISSN:  1521-6934     ISO Abbreviation:  Best Pract Res Clin Obstet Gynaecol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-03     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101121582     Medline TA:  Best Pract Res Clin Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  341-53     Citation Subset:  IM    
Department of Endocrinology, Manchester Royal Infirmary, Manchester M13 9WL, UK.
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MeSH Terms
Antineoplastic Agents / therapeutic use
Dopamine Agonists / therapeutic use
Drug Resistance
Hyperprolactinemia / diagnosis,  drug therapy*,  etiology*
Pituitary Neoplasms / complications,  drug therapy
Pregnancy Complications / drug therapy
Prolactinoma / complications,  drug therapy
Reg. No./Substance:
0/Antineoplastic Agents; 0/Dopamine Agonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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