| Hyperpolarized krypton-83 as a contrast agent for magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 16344474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For the first time, magnetic resonance imaging (MRI) with hyperpolarized (hp) krypton-83 (83Kr) has become available. The relaxation of the nuclear spin of 83Kr atoms (I = 9/2) is driven by quadrupolar interactions during brief adsorption periods on surrounding material interfaces. Experiments in model systems reveal that the longitudinal relaxation of hp 83Kr gas strongly depends on the chemical composition of the materials. The relaxation-weighted contrast in hp 83Kr MRI allows for the distinction between hydrophobic and hydrophilic surfaces. The feasibility of hp 83Kr MRI of airways is tested in canine lung tissue by using krypton gas with natural abundance isotopic distribution. Additionally, the influence of magnetic field strength and the presence of a breathable concentration of molecular oxygen on longitudinal relaxation are investigated. |
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Authors:
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Galina E Pavlovskaya; Zackary I Cleveland; Karl F Stupic; Randall J Basaraba; Thomas Meersmann |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2005-12-12 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 102 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-21 Completed Date: 2006-01-31 Revised Date: 2010-09-21 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 18275-9 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media / chemistry* Dogs Hydrophobicity Krypton / chemistry* Lung / metabolism Magnetic Resonance Imaging / instrumentation, methods* Magnetics Oxygen |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 7439-90-9/Krypton; 7782-44-7/Oxygen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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