| Hyperpolarization of the cell membrane of mouse hepatocytes by fatty acid oxidation. | |
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MedLine Citation:
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PMID: 7753889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of palmitate and metabolizable and nonmetabolizable monosacharides (D-glucose, D-fructose and 2-deoxy-D-glucose = 2-DG) on the membrane potential (Vm) of mouse hepatocytes was investigated employing a superfused mouse liver slice technique. Palmitate hyperpolarized the liver cell membrane in a concentration dependent manner whereas the monosaccharides tested did not. When mice were fed a fat-rich diet, the hyperpolarisation was greater in comparison to mice fed a low fat diet. The hyperpolarization was reversed by ouabain, an inhibitor of the Na+/K(+)-ATPase, by the K(+)-channel blockers tetra-ethyl-ammonium (TEA) and cetiedil and by three inhibitors of fatty acid oxidation (2-bromopalmitate, 2-bromooctanoate and 4-pentenoate). The results suggest that hyperpolarization of the liver cell membrane is due to fatty acid oxidation and that both activation of Na+/K(+)-ATPase and opening of K(+)-channels are involved. The implications of these findings with regard to control of food intake by fatty acid oxidation are discussed. The results are consistent with a role of the hepatic membrane potential in control of food intake by fatty acid oxidation. |
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Authors:
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R Rossi; M Geronimi; P Gloor; M C Seebacher; E Scharrer |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Physiology & behavior Volume: 57 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-06-21 Completed Date: 1995-06-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 509-14 Citation Subset: IM |
Affiliation:
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Institut für Veterinär-Physiologie, Universität Zürich, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Deoxyglucose / pharmacology Dietary Fats / pharmacology Fatty Acids / metabolism* Fatty Acids, Monounsaturated / pharmacology Female Fructose / pharmacology Glucose / pharmacology Liver / cytology, physiology* Male Membrane Potentials / drug effects* Mice Octanoic Acids / pharmacology Ouabain / pharmacology Oxidation-Reduction Palmitates / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Octanoic Acids; 0/Palmitates; 154-17-6/Deoxyglucose; 18263-25-7/2-bromopalmitate; 2623-82-7/2-bromooctanoate; 30237-26-4/Fructose; 50-99-7/Glucose; 591-80-0/4-pentenoic acid; 630-60-4/Ouabain |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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