Document Detail

Hyperplasia of myoepithelial cells expressing calponin during atrophy of the rat parotid gland induced by duct ligation.
MedLine Citation:
PMID:  12945732     Owner:  NLM     Status:  MEDLINE    
The number and location of myoepithelial cells in the rat parotid gland submitted to surgical ligation of its main excretory duct were studied through immunohistochemical labelling for calponin. These cells were labelled by the streptavidin-biotin method using anti-calponin primary antibody, and their number was determined during each step of glandular atrophy, i.e., at time zero (control) and 1, 7, 15, 21, 30 and 60 days after ligation. Morphological analysis showed a gradual decrease and fibrosis of the glandular lobules accompanied by disappearance of the acini and the occurrence of duct-like structures. The expression of calponin was observed in all specimens analysed, being restricted to myoepithelial cells. Labelling revealed the distribution of myoepithelial cells around the acini and intercalated ducts in the control group and around duct-like structures later during the course of atrophy. Quantitative analysis demonstrated significant increase in the number of myoepithelial cells up to day 7 post-ligation, followed by gradual increases which, however, were not statistically significant. These results suggest that myoepithelial cells proliferate intensely up to day 7 post-ligation, an event that coincides with a higher rate of disappearance of acinar cells. After this period, the elevatednumber of cells observed at the end of the previous period is maintained.
M C C Miguel; E S S Andrade; R Taga; L P Pinto; L B Souza
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Histochemical journal     Volume:  34     ISSN:  0018-2214     ISO Abbreviation:  Histochem. J.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2003-08-29     Completed Date:  2004-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0163161     Medline TA:  Histochem J     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  499-506     Citation Subset:  IM    
Laboratory of Oral Pathology, Dentistry School, Federal University of Rio Grande do Norte, 1787-CEP-59056-000 Natal, Brazil.
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MeSH Terms
Atrophy / complications,  metabolism,  pathology*
Calcium-Binding Proteins / metabolism*
Epithelial Cells / metabolism*,  pathology*
Hyperplasia / complications,  metabolism,  pathology*
Microfilament Proteins
Parotid Gland / metabolism*,  pathology*
Rats, Wistar
Salivary Ducts / physiology,  surgery
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Microfilament Proteins; 0/calponin

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