| Hyperplasia of the juxtaglomerular complex with hyperaldosteronism and hypokalemic alkalosis. A new syndrome. 1962. | |
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MedLine Citation:
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PMID: 9513916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new syndrome, characterized by hypertrophy and hyperplasia of the juxtaglomerular apparatus of the kidneys, aldosteronism resulting from adrenal cortical hyperplasia, and persistently normal blood pressure is described in two patients. Overproduction of aldosterone could not be prevented by sodium loading or by administration of albumin intravenously; it was associated with hypokalemic alkalosis and Pitressin-resistant impairment of urinary concentrating ability. In both subjects, increased amounts of circulating angiotensin were demonstrated; infusion of angiotensin II produced rises of blood pressure in both subjects considerably less than the rises induced by comparable doses in normal subjects. The sequence of events, (1) primary resistance to the pressor action of angiotensin, (2) compensatory overproduction of renin and thus of angiotensin, and (3) stimulation of adrenal cortex by angiotensin is consistent with all the information available about the syndrome. |
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Authors:
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F C Bartter; P Pronove; J R Gill; R C MacCardle |
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Publication Detail:
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Type: Biography; Classical Article; Historical Article; Journal Article |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 9 ISSN: 1046-6673 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 1998 Mar |
Date Detail:
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Created Date: 1998-05-13 Completed Date: 1998-05-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 516-28 Citation Subset: IM; Q |
Affiliation:
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Clinical Endocrinology Branch, National Heart Institute, Bethesda, Maryland, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkalosis
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history*,
physiopathology History, 20th Century Humans Hyperaldosteronism / history*, physiopathology Hyperplasia / history Hypokalemia / history* Juxtaglomerular Apparatus / pathology* Kidney Diseases / history, pathology Male Syndrome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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