| Hyperphosphataemia and hypocalcaemia induced by hypertonic phosphate enema--an experimental study and review of the literature. | |
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MedLine Citation:
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PMID: 1683549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The study objective was to determine the hyperphosphataemic and hypocalcaemic effect of hypertonic phosphate enema. The study was conducted in a department of Internal Medicine at a University Medical Center. 2. Fourteen patients were studied. Patients' mean age (+/- s.d.) was 78.5 +/- 9 years. The creatinine clearance was 48.2 +/- 17.4 ml min-1 (mean +/- s.d.). 3. 500 ml (approx. 7 ml kg-1) of Fleet enema (FE - Na2HPO4.7H2O 224 mmol l-1 and NaH2PO4.H2O 1160 mmol l-1) were administered to each patient. Blood was drawn before FE administration and 1/2, 1, 3, 5, 12 and 24 h thereafter. Serum was analysed for levels of inorganic phosphorus and for calcium. 4. The serum inorganic phosphorus level rose from 1.01 +/- 0.3 mmol l-1 to 1.4 +/- 0.5 mmol l-1 (P = 0.001) 1 h after FE was administered. Serum calcium decreased from 2.32 +/- 0.12 mmol l-1 to 2.12 +/- 0.1 mmol l-1 (P less than 0.001) 12 h after FE was administered. 5. We conclude that FE carries a potential risk for acutely ill elderly patients. To avoid untoward effects due to hyperphosphataemia and hypocalcaemia, the phosphate load must be adjusted to the patient's renal function, i.e. enema volume is to be lowered when phosphate concentration is high, so that if renal function is compromised the amount of phosphate absorbed does not exceed renal excretion capacity. |
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Authors:
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I Grosskopf; E Graff; G Charach; G Binyamin; S Spinrad; I Blum |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Human & experimental toxicology Volume: 10 ISSN: 0960-3271 ISO Abbreviation: Hum Exp Toxicol Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1992-01-08 Completed Date: 1992-01-08 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9004560 Medline TA: Hum Exp Toxicol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 351-5 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine C, Rokach Hospital, Tel-Aviv, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Child, Preschool Enema / adverse effects* Female Humans Hypertonic Solutions Hypocalcemia / chemically induced* Infant Male Middle Aged Phosphorus / blood* |
| Chemical | |
Reg. No./Substance:
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0/Hypertonic Solutions; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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