Document Detail

Hyperphagic effects of brainstem ghrelin administration.
MedLine Citation:
PMID:  12941764     Owner:  NLM     Status:  MEDLINE    
The role of ghrelin in feeding control has been addressed from a largely hypothalamic perspective, with little attention directed at ingestive consequences of stimulation of the peptide's receptor, the growth hormone secretagogue receptor (GHS-R), in the caudal brainstem. Here, we demonstrate a hyperphagic response to stimulation of GHS-R in the caudal brainstem. Ghrelin (150 pmol) delivered to the third and fourth ventricles significantly and comparably increased cumulative food intake, with maximal response approximately 3 h after injection. The meal patterning effects underlying this hyperphagia were also similar for the two placements (i.e., significant reduction in the time between injection and first-meal onset, an increase in the number of meals taken shortly after the injection, and a trend toward an increase in the average size of the first meals that approached but did not achieve statistical significance). In a separate experiment, ghrelin microinjected unilaterally into the dorsal vagal complex (DVC) significantly increased food intake measured 1.5 and 3 h after treatment. The response was obtained with a 10-pmol dose, establishing the DVC as a site of action with at least comparable sensitivity to that reported for the arcuate nucleus. Taken together, the results affirm a caudal brainstem site of action and recommend further investigation into multisite interactions underlying the modulation of ingestive behavior by ghrelin.
Lucy F Faulconbridge; David E Cummings; Joel M Kaplan; Harvey J Grill
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes     Volume:  52     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-27     Completed Date:  2003-10-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2260-5     Citation Subset:  AIM; IM    
Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
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MeSH Terms
Brain Stem / drug effects*,  physiology*
Eating / drug effects,  physiology
Feeding Behavior / drug effects,  physiology
Fourth Ventricle
Hyperphagia / physiopathology*
Injections, Intraventricular
Peptide Hormones / pharmacology*,  physiology
Rats, Sprague-Dawley
Third Ventricle
Grant Support
Reg. No./Substance:
0/Ghrelin; 0/Peptide Hormones

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