| Hyperphagia in rats produced by a mixture of fat and sugar. | |
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MedLine Citation:
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PMID: 2326345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hyperphagic and weight-promoting effects of feeding rats a sugar-fat mixture were compared to those of presenting only one of the two nutrients. Experimental groups were fed sugar (sucrose), fat (corn oil), or a sugar-fat mixture as an option to chow; options were in the form of water solutions or emulsions. The control group was fed only chow. The sugar-fat group displayed a robust hyperphagia (greater than 36%), relative to the control group; the hyperphagic response was greater than that observed in the fat group but not in the sugar group. The sugar-fat group selected more calories from the option than the other two experimental groups. Body weight gains were also greater in the sugar-fat group than in the fat and sugar groups. Addition of saccharin to the fat emulsion increased fat and total intakes to levels close to those of the sugar-fat mixture. In a second experiment, the relative palatability of the plain and sweet fat emulsions was assessed with two-bottle preference tests. The sugar-fat mixture was preferred to the saccharin-fat mixture, which in turn was preferred to the plain-fat emulsion. These results suggest that the sweetness of the sugar-fat mixture contributed to the pronounced hyperphagia and obesity obtained with this diet option. |
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Authors:
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F Lucas; A Sclafani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Physiology & behavior Volume: 47 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-05-21 Completed Date: 1990-05-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 51-5 Citation Subset: IM |
Affiliation:
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Department of Psychology, Brooklyn College, NY 11210. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Corn Oil / pharmacology* Diet Emulsions Energy Intake / drug effects Female Food Preferences Hyperphagia / etiology* Plant Oils / pharmacology* Rats Rats, Inbred Strains Saccharin / pharmacology* Sucrose / pharmacology* Weight Gain / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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DK-26687/DK/NIDDK NIH HHS; DK-31135/DK/NIDDK NIH HHS; MH43332/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Emulsions; 0/Plant Oils; 57-50-1/Sucrose; 8001-30-7/Corn Oil; 81-07-2/Saccharin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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