| Hyperparathyroidism associated with distal tubular dysfunction but intact reabsorption of protein in the proximal tubules. | |
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MedLine Citation:
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PMID: 93849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The urinary output of beta 2-microglobulin was measured in ten hypercalcemic patients undergoing surgery because of hyperparathyroidism. In three subjects the beta 2-microglobulin excretion was abnormally increased and in seven patients it was normal before surgery. Three of these seven patients displayed markedly impaired distal tubular function with a reduced urinary concentration capacity. After surgery all patients became normocalcemic and the urinary concentrating capacities improved. The beta 2-microglobulin excretion, on the other hand, remained unchanged. Thus, hypercalcemia per se does not readily affect the proximal tubular function of reabsorbing low molecular weight proteins. "Tubular proteinuria", if found in patients with hypercalcemia, should be suspected to reflect damage to the kidney by additional mechanisms. |
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Authors:
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L Wibell; P A Dahlberg; A Karlsson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta medica Scandinavica Volume: 206 ISSN: 0001-6101 ISO Abbreviation: Acta Med Scand Publication Date: 1979 |
Date Detail:
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Created Date: 1980-04-23 Completed Date: 1980-04-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370330 Medline TA: Acta Med Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 507-10 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Beta-Globulins / urine* Female Humans Hypercalcemia / complications*, physiopathology, therapy Hyperparathyroidism / complications*, physiopathology, surgery Kidney Concentrating Ability Kidney Diseases / etiology Kidney Tubules / physiopathology* Kidney Tubules, Distal / physiopathology* Kidney Tubules, Proximal / metabolism, physiology* Male Middle Aged beta 2-Microglobulin / metabolism, urine* |
| Chemical | |
Reg. No./Substance:
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0/Beta-Globulins; 0/beta 2-Microglobulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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