| Hyperoxia and tidal volume: Independent and combined effects on neonatal pulmonary inflammation. | |
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MedLine Citation:
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PMID: 16534192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Hyperoxia and tidal volume mechanical ventilation are independent factors in the genesis of lung injury, but it remains unclear the extent to which each is responsible or contributes to this process in newborns. OBJECTIVES: To study the independent and combined effects of hyperoxia and tidal volume mechanical ventilation on the induction of lung inflammation in a newborn piglet model of ventilator-induced lung injury. METHODS: Following exposure to either ambient air or F(I)O2 = 1.0 for a period of 3 days, newborn piglets were randomized to receive mechanical ventilation with either high tidal volume (20 ml/kg) or low tidal volume (6 ml/kg) for 4 h while controlling for pH. RESULTS: Monocyte chemoattractant protein-1 level in the lungs of animals randomized to hyperoxia with high tidal volume ventilation was significantly elevated, compared to all other groups (p < 0.05). Myeloperoxidase assayed in lung homogenate was found to be significantly higher in nonventilated animals exposed to hyperoxia (p < 0.01). Only in animals previously exposed to hyperoxia did the addition of high tidal volume ventilation further increase the level of myeloperoxidase present (p < 0.05). Pulmonary vascular resistance was significantly elevated after 4 h of mechanical ventilation compared to 1 h (p < 0.001). CONCLUSIONS: We conclude that in neonatal piglets undergoing hyperoxic stress, superimposition of high tidal volume ventilation exacerbates the lung inflammation as assessed by lung monocyte chemoattractant protein-1 and level of myeloperoxidase. |
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Authors:
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Carey A Ehlert; William E Truog; Donald W Thibeault; Uttam Garg; Mike Norberg; Mo Rezaiekhaligh; Sherry Mabry; Ikechukwu I Ekekezie |
Publication Detail:
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Type: Journal Article Date: 2006-03-14 |
Journal Detail:
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Title: Biology of the neonate Volume: 90 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2006 |
Date Detail:
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Created Date: 2006-08-10 Completed Date: 2006-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: Switzerland |
Other Details:
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Languages: eng Pagination: 89-97 Citation Subset: IM |
Copyright Information:
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Copyright 2006 S. Karger AG, Basel. |
Affiliation:
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Section of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Mo., USA. cehlert@mail.mcw.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Bronchoalveolar Lavage Fluid / chemistry Chemokine CCL2 / analysis, genetics, metabolism Gene Expression Regulation Hyperoxia / metabolism, physiopathology* Interleukin-1beta / analysis, genetics, metabolism Lung / blood supply, metabolism, pathology Male Peroxidase / genetics, metabolism Pneumonia / etiology*, metabolism, physiopathology* RNA, Messenger / genetics, metabolism Respiration, Artificial / adverse effects Swine Tidal Volume / physiology* Tumor Necrosis Factor-alpha / analysis, genetics, metabolism Vascular Resistance / physiology |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL2; 0/Interleukin-1beta; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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