Document Detail

Hyperoxia and tidal volume: Independent and combined effects on neonatal pulmonary inflammation.
MedLine Citation:
PMID:  16534192     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hyperoxia and tidal volume mechanical ventilation are independent factors in the genesis of lung injury, but it remains unclear the extent to which each is responsible or contributes to this process in newborns. OBJECTIVES: To study the independent and combined effects of hyperoxia and tidal volume mechanical ventilation on the induction of lung inflammation in a newborn piglet model of ventilator-induced lung injury. METHODS: Following exposure to either ambient air or F(I)O2 = 1.0 for a period of 3 days, newborn piglets were randomized to receive mechanical ventilation with either high tidal volume (20 ml/kg) or low tidal volume (6 ml/kg) for 4 h while controlling for pH. RESULTS: Monocyte chemoattractant protein-1 level in the lungs of animals randomized to hyperoxia with high tidal volume ventilation was significantly elevated, compared to all other groups (p < 0.05). Myeloperoxidase assayed in lung homogenate was found to be significantly higher in nonventilated animals exposed to hyperoxia (p < 0.01). Only in animals previously exposed to hyperoxia did the addition of high tidal volume ventilation further increase the level of myeloperoxidase present (p < 0.05). Pulmonary vascular resistance was significantly elevated after 4 h of mechanical ventilation compared to 1 h (p < 0.001). CONCLUSIONS: We conclude that in neonatal piglets undergoing hyperoxic stress, superimposition of high tidal volume ventilation exacerbates the lung inflammation as assessed by lung monocyte chemoattractant protein-1 and level of myeloperoxidase.
Carey A Ehlert; William E Truog; Donald W Thibeault; Uttam Garg; Mike Norberg; Mo Rezaiekhaligh; Sherry Mabry; Ikechukwu I Ekekezie
Publication Detail:
Type:  Journal Article     Date:  2006-03-14
Journal Detail:
Title:  Biology of the neonate     Volume:  90     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2006  
Date Detail:
Created Date:  2006-08-10     Completed Date:  2006-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  89-97     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Section of Neonatal-Perinatal Medicine, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, Mo., USA.
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MeSH Terms
Animals, Newborn
Bronchoalveolar Lavage Fluid / chemistry
Chemokine CCL2 / analysis,  genetics,  metabolism
Gene Expression Regulation
Hyperoxia / metabolism,  physiopathology*
Interleukin-1beta / analysis,  genetics,  metabolism
Lung / blood supply,  metabolism,  pathology
Peroxidase / genetics,  metabolism
Pneumonia / etiology*,  metabolism,  physiopathology*
RNA, Messenger / genetics,  metabolism
Respiration, Artificial / adverse effects
Tidal Volume / physiology*
Tumor Necrosis Factor-alpha / analysis,  genetics,  metabolism
Vascular Resistance / physiology
Reg. No./Substance:
0/Chemokine CCL2; 0/Interleukin-1beta; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; EC

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