| Hyperoxia promotes electroretinogram recovery after retinal artery occlusion in cats. | |
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MedLine Citation:
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PMID: 15452078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This work assessed the hypotheses that (1) hyperoxia is preferable to air breathing during retinal arterial occlusion, (2) hyperoxia during occlusion is beneficial in promoting recovery from arterial occlusion, and (3) hyperoxia has value even if it is delayed relative to the onset of the occlusion. METHODS: Reversible branch retinal artery occlusion was produced by pressing with a glass probe onto an artery emerging from the superior part of the optic disc in the retina of anesthetized cats. During 2-hour occlusion episodes, the cats breathed 100% O(2), 1 hour of air and 1 hour of 100% O(2), 1 hour of air and 1 hour of 70% O(2), or air. Intraretinal ERGs were recorded before, during, and after the occlusion. RESULTS: Hyperoxia during occlusion preserved intraretinal b-wave amplitude at 86% +/- 12% of normal; longer durations of increased oxygenation maintained the b-wave at higher levels during occlusion and increased the probability of b-wave recovery after occlusion; higher O(2) content in the breathing gas increased b-wave amplitude during recovery; and hyperoxia during occlusion decreased the time it took for the b-wave to recover after the occlusion. CONCLUSIONS: Hyperoxia is preferable to air breathing during retinal arterial occlusion not only for maintaining b-wave amplitude during occlusion, but also for providing a shorter recovery time and better percentage recovery after the end of the occlusion. Even if it is not possible to begin hyperoxia at the onset of occlusion, it may still be valuable. |
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Authors:
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Gülnur Birol; Ewa Budzynski; Norbert D Wangsa-Wirawan; Robert A Linsenmeier |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: 45 ISSN: 0146-0404 ISO Abbreviation: Invest. Ophthalmol. Vis. Sci. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-09-28 Completed Date: 2004-11-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 3690-6 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208-3107, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cats Dark Adaptation Electroretinography Hyperoxia / physiopathology* Male Oxygen / administration & dosage Oxygen Consumption / physiology Recovery of Function / physiology Respiration Retina / physiology* Retinal Artery Occlusion / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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EY05034/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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