Document Detail

Hyperoxia in very preterm infants: a systematic review of the literature.
MedLine Citation:
PMID:  21825917     Owner:  NLM     Status:  In-Data-Review    
Supplemental oxygen plays a critical role in the management of infants born at the lower limit of viability, but not without the risk of complications resulting from high levels or prolonged exposure. Longitudinal studies of very premature infants, born at less than 28 weeks' gestation, establish a clear relationship between pulse oximetry saturation readings above 92%, or hyperoxia, and development of severe retinopathy of prematurity, chronic lung disease, and brain injury. Hyperoxia is neither natural nor random. It is an unintended consequence of intervention. A comprehensive review of the literature reveals a strong association between exposure to hyperoxia and subsequent expression of comorbidities. Owing to this knowledge, eradication of hyperoxia, and consequent reduction of sequelae, is a significant public health concern that deserves attention by the neonatal community. Although prospective, collaborative meta-analyses will soon provide needed additional data to inform practice, existing compelling evidence supports urgent practice change to reduce exposure to hyperoxia in very preterm infants.
Charlene Deuber; Mary Terhaar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of perinatal & neonatal nursing     Volume:  25     ISSN:  1550-5073     ISO Abbreviation:  J Perinat Neonatal Nurs     Publication Date:    2011 Jul-Sep
Date Detail:
Created Date:  2011-08-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801387     Medline TA:  J Perinat Neonatal Nurs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  268-74     Citation Subset:  N    
Johns Hopkins University and the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (Dr Deuber); and Johns Hopkins University, Baltimore, Maryland (Dr Terhaar).
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