Document Detail

Hyperoxia effects on pulmonary pressure: volume characteristics and lavage surfactant phospholipid in the newborn rabbit.
MedLine Citation:
PMID:  6547862     Owner:  NLM     Status:  MEDLINE    
The effect of hyperoxia (greater than 95%) on surfactant phospholipid recovered by lavage and pulmonary pressure:volume characteristics was studied in rabbits exposed from birth through 4 days of life. Decreased surfactant phospholipid (microgram/mg dry lung weight) in the airways was observed as early as 6 h and persisted through 96 h of life in hyperoxia-exposed animals. The composition of lavage phospholipids and fatty acid profile of phosphatidylcholine was not altered by hyperoxia. Pressure:volume analysis revealed a decrease in maximum lung distensibility (V30, volume at 30 cm pressure) at 48 and 96 h and a decrease in inflation compliance (P30i, pressure on inflation to 30% V30) at 48 h of life in newborn pups exposed to hyperoxia. Pressure:volume changes in both male and female newborns were observed with hyperoxia exposure. However, only female pups exhibited a decrease in lavage phospholipid content as measured at 48 h. These data suggest that the newborn rabbit surfactant system is susceptible to oxygen toxicity. In addition to age-related differences, sex differences may exist with regard to susceptibility to hyperoxia. Subtle alterations in the surfactant system at this critical time of rapid lung development could have long lasting effects on lung function.
J A Ward; R J Roberts
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  46     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-25     Completed Date:  1984-10-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  139-48     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Gestational Age
Lung / metabolism
Lung Compliance
Oxygen / physiology*
Oxygen Inhalation Therapy*
Phospholipids / metabolism*
Pulmonary Surfactants / metabolism*
Sex Factors
Grant Support
Reg. No./Substance:
0/Phospholipids; 0/Pulmonary Surfactants; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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