Document Detail


Hyperoxia during early reperfusion does not increase ischemia/reperfusion injury.
MedLine Citation:
PMID:  21636285     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Oxygen is routinely administered to patients undergoing acute myocardial infarction as well as during revascularization procedures and cardiac surgery. Because reactive oxygen species are mediators of ischemia/reperfusion injury, increased oxygen availability might theoretically aggravate myocardial injury during reperfusion. We hypothesized that ventilation with a hyperoxic gas at start of reperfusion might increase ischemia/reperfusion injury.
METHODS: Rats were anesthetized with isoflurane and ventilated with 40% oxygen. The animals were subjected to 40 min of regional myocardial ischemia and 120 min of reperfusion. In the test group, rats (n=11) were ventilated with a normobaric hyperoxic gas (95% O2) during the last 10 min of ischemia and the first 10 min of reperfusion. Control rats (n=14) were ventilated with 40% O2 throughout the experiments. Due to irreversible reperfusion arrhythmias, one animal in the hyperoxia group and six animals in the control group were excluded. Hearts (n=8 in the control group and n=10 in the test group) were harvested for measurement of infarct size.
RESULTS: The incidence of lethal arrhythmias was 1/11 in the test group and 6/14 in the control group (p=0.06). Reperfusion with normobaric hyperoxia did not influence infarct size (20±8% of area at risk) compared with the normoxia group (24±8% and of area at risk), respectively (mean±SD, p>0.2).
CONCLUSION: Normobaric hyperoxia during early reperfusion did not increase ischemia/reperfusion injury.
Authors:
Lars Henrik Mariero; Arkady Rutkovskiy; Kåre-Olav Stensløkken; Jarle Vaage
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery     Volume:  41     ISSN:  1873-734X     ISO Abbreviation:  Eur J Cardiothorac Surg     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-03-01     Completed Date:  2012-05-01     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8804069     Medline TA:  Eur J Cardiothorac Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  149-53     Citation Subset:  IM    
Affiliation:
Faculty of Medicine, Department of Molecular Biosciences, University of Oslo, and Institute for Experimental Medical Research, Department of Surgery, Oslo University Hospital, Oslo, Norway. l.h.mariero@medisin.uio.no
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Heart Rate / physiology
Hyperoxia / blood,  complications*
Male
Myocardial Infarction / blood,  etiology,  pathology
Myocardial Reperfusion / methods*
Myocardial Reperfusion Injury / blood,  etiology*,  pathology
Oxygen / blood
Oxygen Inhalation Therapy / adverse effects
Partial Pressure
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
7782-44-7/Oxygen
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