Document Detail

Hypernoradrenergic innervation and vascular smooth muscle hyperplastic change.
MedLine Citation:
PMID:  2001467     Owner:  NLM     Status:  MEDLINE    
Two distinguishing features of the vasculature of the spontaneously hypertensive rat (SHR) are an increased sympathetic innervation and vascular smooth muscle hyperplasia. Evidence supporting the existence of hypernoradrenergic innervation and vascular smooth muscle cell hyperplasia is presented with emphasis upon the possible interrelationships between the two events. The results of experiments designed to explore this relationship are presented and include the determination of the role of endogenous nerve growth factor (NGF) and the influence of exogenous NGF on the development of sympathetic innervation of blood vessels and blood pressure change. Attention is focused upon elevated levels of 3-methylhistidine (a biochemical marker for contractile proteins) in the mesenteric vasculature of the SHR. The potential relationships between hypernoradrenergic innervation and increased concentrations of 3-methylhistidine are explored.
R J Head
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Blood vessels     Volume:  28     ISSN:  0303-6847     ISO Abbreviation:  Blood Vessels     Publication Date:  1991  
Date Detail:
Created Date:  1991-04-12     Completed Date:  1991-04-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0427130     Medline TA:  Blood Vessels     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  IM    
CSIRO, Division of Human Nutrition, Hypertension Research Unit, Adelaide, Australia.
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MeSH Terms
Hypertension / pathology,  physiopathology
Methylhistidines / metabolism
Muscle, Smooth, Vascular / innervation*,  pathology
Nerve Growth Factors / physiology
Norepinephrine / metabolism*
Rats, Inbred SHR
Grant Support
Reg. No./Substance:
0/Methylhistidines; 0/Nerve Growth Factors; 368-16-1/3-methylhistidine; 51-41-2/Norepinephrine

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