| Hypernoradrenergic innervation and vascular smooth muscle hyperplastic change. | |
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MedLine Citation:
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PMID: 2001467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two distinguishing features of the vasculature of the spontaneously hypertensive rat (SHR) are an increased sympathetic innervation and vascular smooth muscle hyperplasia. Evidence supporting the existence of hypernoradrenergic innervation and vascular smooth muscle cell hyperplasia is presented with emphasis upon the possible interrelationships between the two events. The results of experiments designed to explore this relationship are presented and include the determination of the role of endogenous nerve growth factor (NGF) and the influence of exogenous NGF on the development of sympathetic innervation of blood vessels and blood pressure change. Attention is focused upon elevated levels of 3-methylhistidine (a biochemical marker for contractile proteins) in the mesenteric vasculature of the SHR. The potential relationships between hypernoradrenergic innervation and increased concentrations of 3-methylhistidine are explored. |
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Authors:
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R J Head |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Blood vessels Volume: 28 ISSN: 0303-6847 ISO Abbreviation: Blood Vessels Publication Date: 1991 |
Date Detail:
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Created Date: 1991-04-12 Completed Date: 1991-04-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0427130 Medline TA: Blood Vessels Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 173-8 Citation Subset: IM |
Affiliation:
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CSIRO, Division of Human Nutrition, Hypertension Research Unit, Adelaide, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Hyperplasia Hypertension / pathology, physiopathology Methylhistidines / metabolism Muscle, Smooth, Vascular / innervation*, pathology Nerve Growth Factors / physiology Norepinephrine / metabolism* Rats Rats, Inbred SHR |
| Grant Support | |
ID/Acronym/Agency:
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HL36885/HL/NHLBI NIH HHS; KO4HL1228/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Methylhistidines; 0/Nerve Growth Factors; 368-16-1/3-methylhistidine; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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