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MedLine Citation:
PMID:  23057958     Owner:  NLM     Status:  Publisher    
Acquired hypernatremia in hospitalized patients is often associated with poorer outcomes. Our aim was to evaluate the relationship between acquired hypernatremia and outcome in children with severe traumatic brain injury (sTBI). We performed a retrospective cohort study of all severely injured trauma patients (Injury Severity Score≥12) with sTBI (GCS≤8 and MAIS≥4) admitted to a Paediatric Critical Care Unit (PCCU; 2000-09). Of 165 patients included, 76% had normonatremia [135-150 mmol/L], 18% had hypernatremia [151-160 mmol/L] and 6% had severe hypernatremia [>160 mmol/L]. The groups were similar except for lower GCS (p=0.002) and increased incidence of fixed pupil(s) on admission in both hypernatremia groups (p<0.001). Mortality rate was 4-fold and 6-fold greater with hypernatremia and severe hypernatremia, respectively (p<0.001), and mortality rates were unchanged when patients with fixed pupils or those with central diabetes insipidus were excluded (p<0.001). Hypernatremic patients had fewer ventilator-free days (p<0.001). Survivors with hypernatremia had greater PCCU (p=0.001) and hospital (p=0.031) lengths of stays, and were less frequently discharged home (p=0.008). Logistic regression analyses of patient characteristics and sTBI interventions demonstrated that hypernatremia was independently associated with the presence of fixed pupil(s) on admission (OR 5.38; p=0.003); administration of thiopental (OR 8.64; p=0.014) and development of central diabetes insipidus (OR 5.66; p=0.005). Additional logistic regression analyses demonstrated a significant association between hypernatremia and mortality (OR 6.660; p=0.034). In summary, acquired hypernatremia appears to signal higher risk of mortality in paediatric sTBI and is associated with a higher discharge level of care in sTBI survivors.
Ibrahim Alharfi; Tanya Charyk Stewart; Shawn Kelly; Gavin Morrison; Douglas Fraser
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Journal of neurotrauma     Volume:  -     ISSN:  1557-9042     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Western University, Pediatrics, London, Ontario, Canada;
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