Document Detail

Hypermetabolic syndrome as a consequence of repeated psychological stress in mice.
MedLine Citation:
PMID:  18325986     Owner:  NLM     Status:  MEDLINE    
Stress is a powerful modulator of neuroendocrine, behavioral, and immunological functions. After 4.5-d repeated combined acoustic and restraint stress as a murine model of chronic psychological stress, severe metabolic dysregulations became detectable in female BALB/c mice. Stress-induced alterations of metabolic processes that were found in a hepatic mRNA expression profiling were verified by in vivo analyses. Repeatedly stressed mice developed a hypermetabolic syndrome with the severe loss of lean body mass, hyperglycemia, dyslipidemia, increased amino acid turnover, and acidosis. This was associated with hypercortisolism, hyperleptinemia, insulin resistance, and hypothyroidism. In contrast, after a single acute stress exposure, changes in expression of metabolic genes were much less pronounced and predominantly confined to gluconeogenesis, probably indicating that metabolic disturbances might be initiated already early but will only manifest in repeatedly stressed mice. Thus, in our murine model, repeated stress caused severe metabolic dysregulations, leading to a drastic reduction of the individual's energy reserves. Under such circumstances stress may further reduce the ability to cope with new stressors such as infection or cancer.
Maren Depke; Gerhard Fusch; Grazyna Domanska; Robert Geffers; Uwe Völker; Christine Schuett; Cornelia Kiank
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-06
Journal Detail:
Title:  Endocrinology     Volume:  149     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-21     Completed Date:  2008-08-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2714-23     Citation Subset:  AIM; IM    
Ernst-Moritz-Arndt-University, Interfaculty Institute of Genetics and Functional Genomics, 17487 Greifswald, Germany.
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MeSH Terms
Acoustic Stimulation
Acute Disease
Disease Models, Animal
Drinking Behavior / physiology
Energy Intake / physiology
Energy Metabolism*
Metabolic Syndrome X / etiology*
Mice, Inbred BALB C
Oligonucleotide Array Sequence Analysis
Polymerase Chain Reaction
Stress, Psychological / genetics,  physiopathology*
Reg. No./Substance:

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