Document Detail

Hypermagnesemia following aluminum phosphide poisoning.
MedLine Citation:
PMID:  2026469     Owner:  NLM     Status:  MEDLINE    
Aluminum phosphide (ALP) is highly toxic to the lungs, heart and blood vessels causing pulmonary edema, shock and arrhythmias. There is massive focal myocardial damage resulting in raised cardiac enzymes. This study included 92 patients of proven ALP poisoning. The age varied between 20-50 years and the majority (74) were females. Clinical manifestations were nausea and vomiting (92), dyspnea and palpitation (72 each), cyanosis (54), hypotension (32) and shock (46) etc. Cardiac arrhythmias were present in 80 cases and hypermagnesemia in 78 patients. Mean serum magnesium level (1.95 +/- 0.18 mE/l) was significantly (p less than 0.01) raised compared to mean magnesium level in control subjects (1.62 +/- 0.26 mEq/l). Hypermagnesemia results from myocardial and liver damage and to our knowledge has not been described in the literature. Of 92 cases studied, 66 died, 60 of whom died within 24 hours of ALP ingestion. Treatment is supportive.
R B Singh; R G Singh; U Singh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  29     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-06-13     Completed Date:  1991-06-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  82-5     Citation Subset:  IM    
Medical Hospital and Research Centre, Civil Lines, Moradabad, India.
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MeSH Terms
Aluminum Compounds*
Electrocardiography / drug effects
Magnesium / blood*
Middle Aged
Phosphines / poisoning*
Sodium / blood
Suicide, Attempted
Reg. No./Substance:
0/Aluminum Compounds; 0/Phosphines; 20859-73-8/aluminum phosphide; 7439-95-4/Magnesium; 7440-23-5/Sodium

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