| Hyperlipidemic myeloma: review of 53 cases. | |
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MedLine Citation:
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PMID: 19921193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperlipidemic myeloma is a rare and poorly understood variant of multiple myeloma. We report the case of a 53-year-old woman with hyperlipidemic myeloma, skin xanthomas and hyperviscosity syndrome who underwent allogeneic bone marrow transplantation. A comprehensive literature search identified 52 additional cases with plasma cell disease and hyperlipidemia. A detailed analysis revealed several characteristics of these patients as compared to multiple myeloma with normal lipid status: (1) IgA paraprotein was present in the majority (53% vs. 21% in classical multiple myeloma). (2) Skin xanthomas, especially in the palmar creases, elbows, and knees were common (70%). (3) Hyperviscosity syndrome occurred more often (26% vs. 2-6%). While conventional lipid-lowering therapy had only marginal effects, successful anti-myeloma therapy also reduced hyperlipidemia. Analyses of the mechanisms leading to hyperlipidemia documented complexes of paraprotein and lipoprotein in 75% of the 32 cases tested, suggesting an inhibitory role of the paraprotein on lipid degradation. In conclusion, the clinical characteristics, the therapeutic options, and the pathophysiologic mechanisms of hyperlipidemic myeloma are comprehensively reported using the available data from all 53 published cases in the literature. |
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Authors:
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Benjamin Misselwitz; Jeroen S Goede; Bernhard C Pestalozzi; Urs Schanz; Jörg D Seebach |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-11-17 |
Journal Detail:
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Title: Annals of hematology Volume: 89 ISSN: 1432-0584 ISO Abbreviation: Ann. Hematol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-04-27 Revised Date: 2010-07-29 |
Medline Journal Info:
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Nlm Unique ID: 9107334 Medline TA: Ann Hematol Country: Germany |
Other Details:
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Languages: eng Pagination: 569-77 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University Hospital Zürich, Rämistr 100, 8091 Zürich, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Hematopoietic Stem Cell Transplantation / adverse effects Humans Hyperlipidemias / complications*, diagnosis*, etiology, metabolism Middle Aged Multiple Myeloma / complications*, diagnosis*, etiology, metabolism Paraproteins / metabolism Skin Diseases / complications, diagnosis Transplantation, Homologous / adverse effects Xanthomatosis / complications, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Paraproteins |
| Comments/Corrections | |
Comment In:
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Ann Hematol. 2010 Sep;89(9):939-40
[PMID:
20127090
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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