| A Hyperlipidemic Diet Induces Structural Changes in Cerebral Blood Vessels. | |
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MedLine Citation:
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PMID: 21443455 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The cerebrovascular pathology is an important contributor to the death rate presently. Hyperlipidemia , an established risk factor for cardiovascular diseases, is also incriminated in the neurodegenerative disorders. The aim of this study was to evaluate the effect of a hyperlipidemic (HL) diet on the morphology of the cerebral vessels and on the amyloid deposition in the HL hamster, an accepted model of atherosclerosis. Hamsters fed a HL diet were tested periodically for serum parameters and sacrificed after 3 and 6 months. The methods used were: paraffin embedding, thioflavin S amyloid staining, fluorescence and electron microscopy (EM). Increased serum cholesterol and triglycerides characterized the HL hamsters. The carotid arteries developed fatty streaks after 3 months and atherosclerotic plaques after 6 months HL diet. The brain cortex comprised irregularly shaped microvessels with large perivascular spaces, enlarged endothelial cells (EC) and occasionally a lumen full of lipoprotein particles. The thioflavin S reaction revealed a discreet staining of the capillaries walls; the EC cytoplasm and basal lamina contained a fibrillar material, with a pattern similar to an incipient amyloid deposit. Some large meningeal vessels from animals with serum cholesterol over 1000mg/dl presented an intense autofluorescence in the adventitia; EM examination identified lipid-loaded perivascular cells in these areas. In conclusion, the detected morphological changes induced by the HL diet could represent a serious impairment for the normal brain function. These data may contribute to the better understanding of the risks of hyperlipidemia for the mental health, and its reversal could become a new therapeutic approach for neurodegenerative disorders. |
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Authors:
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Elena Constantinescu; Florentina Safciuc; Anca V Sima |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-28 |
Journal Detail:
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Title: Current neurovascular research Volume: - ISSN: 1875-5739 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101208439 Medline TA: Curr Neurovasc Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Cellular Biology and Pathology "N Simionescu", 8, B.P. Hasdeu Street 050568, Bucharest, Romania. lucia.constantinescu@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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