Document Detail

Hyperlipidemia in pediatric hemodialysis and renal transplant patients. Associated with coronary artery disease.
MedLine Citation:
PMID:  786006     Owner:  NLM     Status:  MEDLINE    
Fasting serum cholesterol and serum triglyceride levels were determined in 15 maintenance hemodialysis (MH) and 35 renal transplant (RT) patients. Fourteen of 15 MH patients (93%) had elevated triglyceride levels (greater than 140 mg/100 ml) compared to 11 of 35 RT recipients (31%) (P less than .001). Two of 15 MH patients (13%) had elevated cholesterol levels (greater than 230 mg/100 ml), compared to 18 of 35 RT recipients (51%) (P = .03). In MH patients, a positive correlation was noted between serum triglyceride levels and carbohydrate intake (P = .03). Autopsy material from 12 children who underwent MH or RT was compared to material from 16 age-matched controls; an increased collagenous content of intima, a possible early indicator of coronary artery disease, was noted more frequently (P less than .006) in index patients compared to controls. Our data demonstrate that hyperlipidemia is a frequent finding in pediatric patients treated with MH and RT, and may be associated with premature coronary artery disease.
A J Pennisi; E T Heuser; M R Mickey; A Lipsey; M H Malekzadeh; R N Fine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of diseases of children (1960)     Volume:  130     ISSN:  0002-922X     ISO Abbreviation:  Am. J. Dis. Child.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-11-01     Completed Date:  1976-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370471     Medline TA:  Am J Dis Child     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  957-61     Citation Subset:  AIM; IM    
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MeSH Terms
Child, Preschool
Cholesterol / blood
Coronary Disease / blood,  etiology*,  pathology
Coronary Vessels / pathology
Dietary Carbohydrates
Hyperlipidemias / blood,  etiology*
Kidney Transplantation*
Postoperative Complications*
Prednisone / therapeutic use
Renal Dialysis / adverse effects*
Transplantation, Homologous / adverse effects
Triglycerides / blood
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Triglycerides; 53-03-2/Prednisone; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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