| Hyperlipidemia in children. | |
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MedLine Citation:
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PMID: 16709475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hyperlipidemia in children has emerged as an increasingly prevalent risk factor in children, concomitant with the worldwide epidemic of obesity. Hyperlipidemia can alter vascular endothelial function and impair some of its pro-fibrinolytic and anti-thrombotic regulatory properties, as well as initiate the atherosclerotic process. There are strong links between vascular changes and hyperlipidemia in children, both from pathologic and non-invasive assessment studies. More severe lipid abnormalities in children are related to primary familial dyslipidemias. Current recommendations for screening begin with assessment of family history for cardiovascular disease or events or parental hyperlipidemia. High-risk individuals merit more intensive investigation and intervention. While fat-restricted diets have been shown to be safe in children, lipid-lowering is modest. Those with more severe lipid abnormalities may meet criteria for drug therapy, and the statin agents commonly used in adults are increasingly being used in high-risk children, with similar efficacy and safety, although long-term concerns remain. |
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Authors:
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Brian W McCrindle |
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Publication Detail:
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Type: Journal Article; Review Date: 2005-02-17 |
Journal Detail:
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Title: Thrombosis research Volume: 118 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-05-19 Completed Date: 2006-08-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: United States |
Other Details:
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Languages: eng Pagination: 49-58 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8. brian.mccrindle@sickkids.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Atherosclerosis / etiology, prevention & control Child Disease Management Dyslipidemias / etiology Humans Hyperlipidemias* / diagnosis, diet therapy, drug therapy Infant Practice Guidelines as Topic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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