Document Detail

Hyperlipidemia in children.
MedLine Citation:
PMID:  16709475     Owner:  NLM     Status:  MEDLINE    
Hyperlipidemia in children has emerged as an increasingly prevalent risk factor in children, concomitant with the worldwide epidemic of obesity. Hyperlipidemia can alter vascular endothelial function and impair some of its pro-fibrinolytic and anti-thrombotic regulatory properties, as well as initiate the atherosclerotic process. There are strong links between vascular changes and hyperlipidemia in children, both from pathologic and non-invasive assessment studies. More severe lipid abnormalities in children are related to primary familial dyslipidemias. Current recommendations for screening begin with assessment of family history for cardiovascular disease or events or parental hyperlipidemia. High-risk individuals merit more intensive investigation and intervention. While fat-restricted diets have been shown to be safe in children, lipid-lowering is modest. Those with more severe lipid abnormalities may meet criteria for drug therapy, and the statin agents commonly used in adults are increasingly being used in high-risk children, with similar efficacy and safety, although long-term concerns remain.
Brian W McCrindle
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Publication Detail:
Type:  Journal Article; Review     Date:  2005-02-17
Journal Detail:
Title:  Thrombosis research     Volume:  118     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-19     Completed Date:  2006-08-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-58     Citation Subset:  IM    
Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada M5G 1X8.
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MeSH Terms
Atherosclerosis / etiology,  prevention & control
Disease Management
Dyslipidemias / etiology
Hyperlipidemias* / diagnosis,  diet therapy,  drug therapy
Practice Guidelines as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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