Document Detail


Hyperlipidemia due to oxymetholone therapy. Occurrence in a long-term hemodialysis patient.
MedLine Citation:
PMID:  180304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Marked hypertriglyceridemia and hypercholesterolemia accompanied by angina and a left cerebral thrombosis occurred in a long-term hemodialysis patient following 5 1/2 weeks of oral treatment with oxymetholone, 100 mg/day, a synthetic androgen. After androgen therapy was discontinued, over a three-month period, plasma lipid values progressively decreased below pretreatment values, and clinical symptoms disappeared. During rechallenge with oxymetholone, serum lipid values increased substantially, and the lipoprotein pattern changed from a type IV to a type V. Detailed lipid studies showed subnormal postheparin lipolytic activity and a fast-migrating pre-beta-lipoprotein in a very-low-density lipoproteins (VLDL) fraction. Because of the data linking lipid abnormalities to atherosclerosis and the acceleration of atherosclerosis in long-term hemodialysis patients, great caution should be exercised in administering androgenic steroids to these patients.
Authors:
R D Reeves; M D Morris; G L Barbour
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  JAMA : the journal of the American Medical Association     Volume:  236     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-09-01     Completed Date:  1976-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  469-72     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Humans
Hypercholesterolemia / chemically induced
Hyperlipidemias / chemically induced*
Kidney Failure, Acute / therapy
Lipoproteins / blood
Lipoproteins, VLDL / blood
Male
Middle Aged
Oxymetholone / administration & dosage,  adverse effects*
Renal Dialysis*
Time Factors
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Lipoproteins; 0/Lipoproteins, VLDL; 0/Triglycerides; 434-07-1/Oxymetholone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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